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The Clinical Impacts of Neutrophil to Lymphocyte Ratio for Esophageal Cancer Patients Who Receive Curative Treatment

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  1. Article

    Open Access

    The Clinical Impact of Change in the C-Reactive Protein/Albumin Ratio in Gastric Cancer Patients Who Receive Curative Treatment

    Recently, change in the C-reactive protein/albumin ratio (CAR) has become a promising prognostic marker in some malignancies. The aim of the present study was to evaluate the clinical impact of change in the C...

    Toru Aoyama, Yukio Maezawa, Itaru Hashimoto in Journal of Gastrointestinal Cancer (2024)

  2. Article

    Open Access

    The Clinical Impact of Change in the Neutrophil to Lymphocyte Ratio During the Perioperative Period in Gastric Cancer Patients Who Receive Curative Gastrectomy

    Recently, change in the neutrophil to lymphocyte ratio (cNLR) has been shown to be a promising prognostic inflammation marker in some malignancies. The aim of the present study was to evaluate the clinical imp...

    Toru Aoyama, Itaru Hashimoto, Yukio Maezawa in Journal of Gastrointestinal Cancer (2024)

  3. Article

    Open Access

    Non-invasive intraductal oncocytic papillary neoplasm forming a protruding lesion toward the duodenum from the accessory papilla: a case report

    Intraductal oncocytic papillary neoplasm (IOPN), previously classified as a subtype of intraductal papillary mucinous neoplasm (IPMN), has been described as an independent disease by the WHO since 2019. IOPN i...

    Shinnosuke Kawahara, Naoto Yamamoto, Kota Washimi, Rei Kanemoto in Surgical Case Reports (2024)

  4. Article

    Open Access

    A case of esophageal cancer in a diverticulum treated by surgical resection: a case report

    An esophageal diverticulum is a relatively rare disease, with reports of treatment for esophageal cancer in the diverticulum even rarer.

    Momoko Fukuda, Toru Aoyama, Norio Yukawa in General Thoracic and Cardiovascular Surger… (2023)

  5. Article

    Open Access

    The clinical impacts of postoperative complications after colon cancer surgery for the clinical course of adjuvant treatment and survival

    We investigated whether or not postoperative complications (POCs) themselves have a negative survival impact or indirectly worsen the survival due to insufficient adjuvant chemotherapy in a pooled analysis of ...

    Toru Aoyama, Koji Oba, Michitaka Honda in International Journal of Clinical Oncology (2023)

  6. Article

    Open Access

    The Comparison of the Dietary Intake Loss Between Elderly and Non-Elderly Patients After Gastrectomy for Gastric Cancer

    The present study quantified the changes in the dietary and nutritional intake after gastrectomy between elderly and non-elderly patients.

    Masato Nakazono, Toru Aoyama, Keisuke Komori in Journal of Gastrointestinal Cancer (2023)

  7. Article

    Open Access

    Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment

    We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment.

    Toru Aoyama, Masato Nakazono, Kenki Segami in Journal of Gastrointestinal Cancer (2023)

  8. Article

    Open Access

    Clinical practice guidelines for duodenal cancer 2021

    Duodenal cancer is considered to be a small intestinal carcinoma in terms of clinicopathology. In Japan, there are no established treatment guidelines based on sufficient scientific evidence; therefore, in dai...

    Kenji Nakagawa, Masayuki Sho, Mitsuhiro Fujishiro in Journal of Gastroenterology (2022)

  9. Article

    Open Access

    Rapid anticalcification treatment for glutaraldehyde-fixed autologous tissue in cardiovascular surgery

    Glutaraldehyde (GA)-fixed autologous tissues, including the pericardium, are widely used as patches and valve substitutes in cardiovascular surgery. However, GA treatment causes tissue calcification. No rapid ...

    Shotaro Kaneko, Susumu Isoda, Toru Aoyama in Journal of Cardiothoracic Surgery (2022)

  10. Article

    Open Access

    Phase II study of an oxaliplatin-based regimen for relapsed colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy (INSPIRE study)

    The aim of this study was to evaluate the efficacy and safety of first-line chemotherapy with re-introduction of oxaliplatin (OX) more than 6 months after adjuvant chemotherapy including OX.

    Keiichiro Ishibashi, Toru Aoyama, Masahito Kotaka in Cancer Chemotherapy and Pharmacology (2021)

  11. Article

    Open Access

    Does the Endoscopic Surgical Skill Qualification System improve patients’ outcome following laparoscopic surgery for colon cancer? A multicentre, retrospective analysis with propensity score matching

    This study aimed to investigate the short-term and oncological impact of the Endoscopic Surgical Skill Qualification System (ESSQS) by the Japan Society for Endoscopic Surgery on the operator performing laparo...

    Keisuke Kazama, Masakatsu Numata, Toru Aoyama in World Journal of Surgical Oncology (2021)

  12. Article

    Open Access

    Lateral lymph node dissection for mid-to-low rectal cancer: is it safe and effective in a practice-based cohort?

    Most evidence regarding lateral lymph node dissection for rectal cancer is from expert settings. This study aimed to evaluate the safety and efficacy of this procedure in a practice-based cohort.

    Masakatsu Numata, Hiroshi Tamagawa, Keisuke Kazama, Shinnosuke Kawahara in BMC Surgery (2021)

  13. Article

    Open Access

    Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature

    Neuroendocrine carcinoma (NEC) originating from the extrahepatic bile duct (EHBD) is very rare but is known for its aggressiveness and poor prognosis. We herein report a case of rapidly progressed NEC in the e...

    Mariko Kamiya, Naoto Yamamoto, Yuto Kamioka, Hirohide Inoue in Surgical Case Reports (2020)

  14. Article

    Open Access

    High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1

    The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for cell proliferation, DNA synthesis, and repair. High GGH expression af...

    Yukio Maezawa, Kentaro Sakamaki, Naohide Oue in Journal of Cancer Research and Clinical On… (2020)

  15. Article

    Equivalent feasibility and safety of perioperative care by ERAS in open and laparoscopy-assisted distal gastrectomy for gastric cancer: a single-institution ancillary study using the patient cohort enrolled in the JCOG0912 phase III trial

    Laparoscopy-assisted distal gastrectomy (LADG) has an advantage of earlier recovery after surgery due to having lower invasiveness and wound pain than open distal gastrectomy (ODG). However, whether the same e...

    Toru Aoyama, Takaki Yoshikawa, Tsutomu Sato, Tsutomu Hayashi in Gastric Cancer (2019)

  16. Article

    Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study

    Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric c...

    Yosuke Atsumi, Yasushi Rino, Hiroo Wada, Yuichi Kitani, Yukihiro Ozawa in Gastric Cancer (2019)

  17. Article

    A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer with early relapse after S-1 adjuvant therapy: XParTS-I trial

    In Japan, standard regimens for advanced gastric cancer (AGC) include S-1 chemotherapy. The standard treatment for early relapse after adjuvant chemotherapy with fluoropyrimidine alone is platinum-based chemot...

    Kazuhiro Nishikawa, Akira Tsuburaya, Takaki Yoshikawa, Masazumi Takahashi in Gastric Cancer (2018)

  18. Article

    Priority of lymph node dissection for proximal gastric cancer invading the greater curvature

    The therapeutic efficacy of dissection of the splenic hilar lymph nodes (#10) has not been fully evaluated in locally advanced proximal gastric cancer (LAGC) invading the greater curvature of the stomach.

    Yukio Maezawa, Toru Aoyama, Takanobu Yamada, Kazuki Kano, Tsutomu Hayashi in Gastric Cancer (2018)

  19. Article

    Does a laparoscopic approach attenuate the body weight loss and lean body mass loss observed in open distal gastrectomy for gastric cancer? a single-institution exploratory analysis of the JCOG 0912 phase III trial

    Laparoscopy-assisted distal gastrectomy (LADG) for gastric cancer may prevent the loss of body weight and lean body mass resulting from reduced surgical stress in comparison to open distal gastrectomy (ODG). A...

    Toru Aoyama, Tsutomu Sato, Tsutomu Hayashi, Takanobu Yamada, Haruhiko Cho in Gastric Cancer (2018)

  20. Article

    Open Access

    Randomized phase III trial comparing surgery alone to UFT + PSK for stage II rectal cancer (JFMC38 trial)

    We conducted a randomized phase III trial comparing tegafur/uracil (UFT) and Polysaccharide-K (PSK) to surgery alone in curatively resected stage II rectal cancer patients.

    Kiyotaka Okuno, Toru Aoyama, Koji Oba in Cancer Chemotherapy and Pharmacology (2018)

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