4 Result(s)
within
Tomonori Kaneko
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessThe spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome. To understand the mechanism of metastasis to inform prognosis and treatment, here we analyze primary and metastasized tumor...
-
Article
Open AccessIdentification and characterization of a large family of superbinding bacterial SH2 domains
Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). Apart from a few isolated cases in viruses, no functional SH2 domain has bee...
-
Article
Open AccessErratum: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Nature Communications 6: Article number: 7721 (2015); Published 13 July 2015; Updated 8 September 2015 The image in Fig. 1h of this Article was inadvertently duplicated from panel i. The correct version of the...
-
Article
Open AccessA phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Although cell migration plays a central role in development and disease, the underlying molecular mechanism is not fully understood. Here we report that a phosphorylation-mediated molecular switch comprising d...
