-
Article
Open AccessCorrection: Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients
-
Article
Open AccessKinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients
SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. However, the molecular basis underlying the excessive yet non-productive immune responses in se...
-
Article
Open AccessThe spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome. To understand the mechanism of metastasis to inform prognosis and treatment, here we analyze primary and metastasized tumor...
-
Article
Open AccessProteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and the human papillomavirus (HPV+)-driven subtype is the fastest rising cancer in North America. Although most cases of HPV
-
Article
Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA
The clinical impact of monitoring serum p53 antibodies, carbohydrate antigen19-9, and carcinoembryonic antigen in patients with colorectal cancer has not been fully evaluated.
-
Article
Open AccessIdentification and characterization of a large family of superbinding bacterial SH2 domains
Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). Apart from a few isolated cases in viruses, no functional SH2 domain has bee...
-
Protocol
Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain
Commercial antibodies raised against phosphotyrosine have been widely used as reagents to detect or isolate tyrosine-phosphorylated proteins from cellular samples. However, these antibodies are costly and are ...
-
Article
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder
A SH2-domain-derived superbinder that exhibits strong affinity for phosphotyrosine (pTyr) was used in conjugation with mass spectroscopy approaches to enrich and enable identification of pTyr sites in differen...
-
Article
Open AccessErratum: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Nature Communications 6: Article number: 7721 (2015); Published 13 July 2015; Updated 8 September 2015 The image in Fig. 1h of this Article was inadvertently duplicated from panel i. The correct version of the...
-
Article
Open AccessA phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Although cell migration plays a central role in development and disease, the underlying molecular mechanism is not fully understood. Here we report that a phosphorylation-mediated molecular switch comprising d...
-
Article
Insolubilization of Cadmium in Paddy Field Using Atomized Iron Powder and Extracting Reagent
The insolubilization of cadmium in the soil of a naturally cadmium-contaminated paddy field was studied using an atomized iron powder and an extracting reagent. Cadmium in the soil was extracted into the water...
-
Article
Open AccessPhosphotyrosine recognition domains: the typical, the atypical and the versatile
SH2 domains are long known prominent players in the field of phosphotyrosine recognition within signaling protein networks. However, over the years they have been joined by an increasing number of other protei...
