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  1. No Access

    Article

    Clinical Parameters for Predicting the Survival in Patients with Squamous and Non-squamous-cell NSCLC Receiving PD-1 Inhibitor Therapy

    We explored the associations between progression-free survival (PFS) after the initiation of PD-1 inhibitor therapy and the clinical parameters in patients with NSCLC. We reviewed the clinical data of patients...

    Minehiko Inomata, Takahiro Hirai, Zenta Seto, Kotaro Tokui… in Pathology & Oncology Research (2020)

  2. No Access

    Article

    CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

    Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chroni...

    Tomomi Ichikawa, Kiyoshi Hirahara, Kota Kokubo, Masahiro Kiuchi… in Nature Immunology (2019)

  3. Article

    Open Access

    Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation

    Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic i...

    Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo… in Inflammation and Regeneration (2018)

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  4. Article

    Open Access

    Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

    The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 imm...

    Naoko Mato, Kiyoshi Hirahara, Tomomi Ichikawa, ** Kumagai… in Scientific Reports (2017)

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  5. No Access

    Article

    Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study

    Cortisol plays an important role in the physical status of patients with end-stage lung cancer, but the association of urine cortisol levels with TNM stage/performance status (PS) is unclear in patients with a...

    Kensuke Suzuki, Tomomi Ichikawa, Hideaki Furuse, Takeshi Tsuda… in Supportive Care in Cancer (2015)

  6. No Access

    Article

    Usefulness of the Palliative Prognostic Index in patients with lung cancer

    The usefulness of the Palliative Prognostic Index (PPI) has been successfully validated in a variety of clinical settings. However, while lung cancer is the leading cause of death worldwide, patients with lung...

    Minehiko Inomata, Ryuji Hayashi, Kotaro Tokui, Chihiro Taka… in Medical Oncology (2014)

  7. Article

    Open Access

    Miliary brain metastasis presenting with calcification in a patient with lung cancer: a case report

    Miliary brain metastasis is an extremely rare form of brain metastasis which can present with atypical imaging findings. We report the case of a patient with miliary brain metastasis of lung cancer showing cal...

    Minehiko Inomata, Ryuji Hayashi, Kenta Kambara… in Journal of Medical Case Reports (2012)

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