10 Result(s)

Article

Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers

Recently in Japan, six workers at a chemical plant that manufactures resins developed interstitial lung diseases after being involved in loading and packing cross-linked water-soluble acrylic acid polymers (CW...

Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai… in Respiratory Research (2023)

Article

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Most toxicological studies on titanium dioxide (TiO₂) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and int...

Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai… in Particle and Fibre Toxicology (2022)

Article

No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer have been extremely reduced. We performed a 26-we...

Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai… in Scientific Reports (2022)

Article

Correction to: Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai… in Particle and Fibre Toxicology (2022)

Article

Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP) at a chemical plant suffered from lung diseases, including fibrosis, interstitial pneumonia, emphysema, and pneumothorax. ...

Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai… in Particle and Fibre Toxicology (2022)

Article

DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis

Leydig cells in the testes produce testosterone in the presence of gonadotropins. Therefore, male testosterone levels must oscillate within a healthy spectrum, given that elevated testosterone levels augment t...

Hong-bin Chen, Jorge Carlos Pineda Garcia, Shinako Arizono… in Scientific Reports (2021)

Article

Improvement in early urinary continence recovery after robotic-assisted radical prostatectomy based on postoperative pelvic anatomic features: a retrospective review

We investigated the impact of postoperative membranous urethral length and other anatomic characteristics of the pelvic floor shape as measured by magnetic resonance imaging on the improvement in continence fo...

Akihiro Nakane, Hiroki Kubota, Yusuke Noda, Tomoki Takeda, Yasuhiko Hirose… in BMC Urology (2019)

Article

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory

The impairment of learning and memory is a well-documented effect of both natural and synthetic cannabinoids. In the present study, we aimed to investigate the effect of acute administration of JWH-018, a synt...

Ren-shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song… in Scientific Reports (2019)