102 Result(s)

Article

New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia: clinical and basic studies for the next generation

 All-trans retinoic acid (ATRA) is a potent differentiation drug for acute promyelocytic leukemia (APL) and is now incorporated into first-line therapy. However, ATRA resistance has become a major clinical proble...

Kunio Kitamura, Hitoshi Kiyoi, Hitoshi Yoshida… in Cancer Chemotherapy and Pharmacology (1997)

Article

Quality of life in adult patients after bone marrow transplantation

Since culture, history, personal financial situation, and the health insurance system are strongly associated with quality of life (QOL) for patients undergoing continuing medical care, any investigation into ...

Kunio Yano, Makoto Yazaki, Kenjiro Kitaori… in International Journal of Clinical Oncology (1998)

Article

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

We have recently identified an internal tandem duplication of the human Flt3 gene in approximately 20% of acute myeloid leukemia (AML) cases. In the present study, the wild-type and the mutant Flt3 genes were ...

Fumihiko Hayakawa, Masayuki Towatari, Hitoshi Kiyoi, Mitsune Tanimoto… in Oncogene (2000)

Article

Immunoglobulin variable region structure and B-Cell malignancies

The enormous diversity of immunoglobulin (Ig) variable (V) gene sequences encoding the antibody repertoire are formed by the somatic recombination of relatively few genetic elements. In B-lineage malignancies,...

Hitoshi Kiyoi, Tomoki Naoe in International Journal of Hematology (2001)

Article

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy

Fusion gene products such as PML-RARα and BCR-ABL generated by leukemia-specific chromosomal translocations have been identified as target molecules for the treatment of leukemia. Here we describe one possibi...

Tomoki Naoe, Hitoshi Kiyoi, Yukiya Yamamoto… in Cancer Chemotherapy and Pharmacology (2001)

Article

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis....

Hitoshi Kiyoi, Ryuzo Ohno, Ryuzo Ueda, Hidehiko Saito, Tomoki Naoe in Oncogene (2002)

Article

Successful Treatment with Imatinib Mesylate of a CML Patient in Megakaryoblastic Crisis with Severe Fibrosis

The prognosis of patients with chronic myeloid leukemia in blastic crisis (CML-BC) remains extremely poor, and multiagent chemotherapy regimens commonly used to treat acute leukemia offer only short-term benef...

Yuka Hirose, Hitoshi Kiyoi, Masanori Iwai… in International Journal of Hematology (2002)

Article

Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation

The transcription factor GATA-1 plays a significant role in erythroid differentiation and association with CBP stimulates its activity by acetylation. It is possible that histone deacetylases (HDACs) repress t...

Kouichi Watamoto, Masayuki Towatari, Yukiyasu Ozawa, Yasuhiko Miyata… in Oncogene (2003)

Article

A Case of Interstitial Pneumonia Induced by Rituximab Therapy

Junji Hiraga, Yasuhiro Kondoh, Hiroyuki Taniguchi… in International Journal of Hematology (2005)

Article

CD56/NCAM-Positive Langerhans Cell Sarcoma: A Clinicopathologic Study of 4 Cases

This report concerns the clinicopathologic features of 4 patients with CD56/neural cell adhesion molecule (NCAM)-positive Langerhans cell sarcoma (LCS). Three of the patients were elderly, between 59 and 62 ye...

Takakazu Kawase, Minoru Hamazaki, Michinori Ogura… in International Journal of Hematology (2005)

Article

BMI-1 is Highly Expressed in M0-Subtype Acute Myeloid Leukemia

Recent studies have suggested that one of the polycomb group genes,BMI- 1, has an important role in the maintenance of normal and leukemic stem cells by repressing theINK4a/ARF locus. Here, we quantitatively exam...

Masashi Sawa, Kazuhito Yamamoto, Toshiya Yokozawa… in International Journal of Hematology (2005)

Article

Assessment of the International Prognostic Scoring System for Determining Chemotherapeutic Indications in Myelodysplastic Syndrome: Japanese Retrospective Multicenter Study

To standardize a rational therapeutic strategy of chemotherapy using the International Prognostic Scoring System (IPSS), we retrospectively analyzed 292 high-risk myelodysplastic syndrome (MDS) patients in 20 ...

Yoshikazu Ito, Kazuma Ohyashiki, Hisamaru Hirai… in International Journal of Hematology (2005)

Protocol

FLT3 Mutations in Acute Myeloid Leukemia

The prevalence of an internal tandem duplication (ITD) of the juxtamembrane domain-coding sequence and a missense mutation of D835 within the kinase domain of the FLT3 gene is 15–35% and 5–10% of adults with acut...

Hitoshi Kiyoi, Tomoki Naoe in Myeloid Leukemia (2006)

Article

Biology, Clinical Relevance, and Molecularly Targeted Therapy in Acute Leukemia with Flt3 Mutation

Overexpression and activating mutations of receptor tyrosine kinases (RTKs) are known to be involved in the pathophys-iology of several kinds of cancer cells. FMS-like receptor tyrosine kinase 3 (FLT3), togeth...

Hitoshi Kiyoi, Tomoki Naoe in International Journal of Hematology (2006)

Article

Stable Engraftment after a Conditioning Regimen with Fludarabine and Melphalan for Bone Marrow Transplantation from an Unrelated Donor

Graft failure and nonrelapse mortality (NRM) are major obstacles after the first unrelated-donor bone marrow transplantation (UD-BMT) with reduced-intensity conditioning. We evaluated UD-BMT with fludarabine (...

Yoshihiro Inamoto, Taku Oba, Koichi Miyamura… in International Journal of Hematology (2006)

Article

Loss of O ⁶-Methylguanine-DNA Methyltransferase Protein Expression Is a Favorable Prognostic Marker in Diffuse Large B-Cell Lymphoma

Although aberrant promoter hypermethylation of O ⁶-methylguanine-DNA methyltransferase (MGMT) is a favorable prognostic marker in patients with diffuse large B-cell lymphoma (DLBCL), MGMT protein expression has n...

Toshihito Ohno, Junji Hiraga, Haruhiko Ohashi… in International Journal of Hematology (2006)

Article

Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A

A 35-year-old patient with hemophilia A presented with rapidly progressive polyarteritis nodosa (PAN). He had been infected with hepatitis B virus (HBV) by repeated transfusion and was positive for hepatitis B...

Tadashi Matsushita, Hiroaki Adachi… in International Journal of Hematology (2006)

Article

High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation

Transplantation-associated thrombotic microangiopathy (TMA) is one of the main complications after hematopoietic stem cell transplantation (HSCT). At the time of onset of gut TMA, a patient developed a high ti...

Tatsuya Adachi, Tadashi Matsushita… in International Journal of Hematology (2006)

Article

Recurrent Intramural Hematoma of the Small Intestine in a Severe Hemophilia A Patient with a High Titer of Factor VIII Inhibitor: A Case Report and Review of the Literature

A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intram...

Akira Katsumi, Tadashi Matsushita, Kanji Hirashima… in International Journal of Hematology (2006)