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Article
Open AccessThe synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial
Maternal depression can be harmful to both mothers and their children. Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been investigated as an alternative intervention for pregnant women with dep...
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Article
Glutamatergic system abnormalities in posttraumatic stress disorder
Accumulating evidence suggests involvement of the glutamatergic system in the biological mechanisms of posttraumatic stress disorder (PTSD), but few studies have demonstrated an association between glutamaterg...
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Article
Open AccessTachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial
Preclinical and clinical studies suggest that supplementation with omega-3 fatty acids after trauma might reduce subsequent posttraumatic stress disorder (PTSD). To date, we have shown in an open trial that PT...
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Article
Open AccessConcern over radiation exposure and psychological distress among rescue workers following the Great East Japan Earthquake Concern over radiation exposure and distress
On March 11, 2011, the Great East Japan Earthquake and tsunami that followed caused severe damage along Japan’s northeastern coastline and to the Fukushima Daiichi nuclear power plant. To date, there are few r...
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Open AccessAttenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: The APOP randomized controlled trial
On March 11, 2011, a magnitude 9.0 earthquake, the most powerful ever recorded in Japan, and a massive tsunami struck off the coast of the Sanriku region. A Disaster Medical Assistance Team, a mobile medical t...
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Article
Fatty Acid Composition of Plasma, Erythrocytes and Adipose: Their Correlations and Effects of Age and Sex
The composition of fatty acids in abdominal subcutaneous adipose tissue and the correlation of fatty acid values of plasma and erythrocytes had not been reported in Japan. The aim of the present study was to i...
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Article
The Depressive Effects of 5,8,11-Eicosatrienoic Acid (20:3n-9) on Osteoblasts
In cases of essential fatty acid deficiency, 5,8,11-eicosatrienoic acid (Mead acid, 20:3n-9) is synthesized from oleic acid as a 20-carbon analog of arachidonic acid. It was reported that 20:3n-9 levels were m...
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Aggression, Fish Oil, and Noradrenergic Activity
Fish oil is known to exert an influence on behavior and mood. We have been studying the effects of fish oil, especially docosahexaenoic acid (DHA), a major active component of fish oil, on aggression in double...
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Article
n−3 long-chain FA decrease serum levels of TG and remnant-like particle-cholesterol in humans
A large number of papers have reported that administration of n−3 FA reduced serum TG concentrations in hypertriglyceridemic patients. However, few studies have examined the effect of n−3 FA on serum concentra...
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Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress
The purpose of the present research was to clarify the effect of docosahexaenoic acid (DHA) intake on behavior and plasma catecholamines (CA). In Study 1, 42 students took either DHA-rich oil capsules containi...
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Article
Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study
We previously found that docosahexaenoic acid (DHA) intake prevents aggression enhancement at times of mental stress. In the present study we investigated changes in aggression under nonstressful conditions. F...
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The effects of infusion of trieicosapentaenoyl-glycerol emulsion on extravascular lung water during myocardial ischemia and reperfusion in dogs
To test the effects of eicosapentaenoic acid (EPA) infusion on pulmonary edema induced by coronary ligation and reperfusion, extravascular lung water (EVLW) was measured in situ by the thermal-dye double indicato...
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Article
Platelet and aorta arachidonic and eicosapentaenoic acid levels andin vitro eicosanoid production in rats fed high-fat diets
There is a significant interest in the interrelationship between long-chain n-3, and n-6 fatty acids due to their ability to modulate eicosanoid production. In general, the intake of arachidonic acid (AA) resu...
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Article
Intravenous injection of tridihomo-γ-linolenoyl-glycerol into mice and its effects on delayed-type hypersensitivity
Highly purified tridihomo-γ-linolenoyl-glycerol (DGLA-TG) was emulsified with egg yolk lecithin as a 10% (wt/vol) DGLA-TG emulsion. We injected 0.05 or 0.5 mL of the emulsion into mice through the tail vein an...
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Article
Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester
Eicosapentaenoic acid (EPA) ethyl ester (1.8 g/d) was administered to 16 diabetic patients (5 insulin-dependent and 11 noninsulin-dependent diabetics) for 6 mon. EPA in total plasma fatty acids increased from ...
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Article
Effect of eicosapentaenoic acid ethyl ester on proteinuria of streptozotocin-induced diabetes mellitus in rats
Streptozotocin (45 mg/kg) was intravenously administered to 7-week-old Wistar rats through their tail veins. After 11 days, the rats were divided into two groups. One group was fed a lipid-free diet (90%, w/w)...
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Article
Injection of tridocosahexaenoyl-glycerol emulsion and fatty acid composition of blood cells
An injectable emulsion of docosahexaenoic acid (DHA) was prepared. One hundred ml of the emulsion contained 3 g of 93%-pure 1,2,3-tridocosahexaenoylglycerol (DHA-TG), 1.2 g of 93%-pure 2-docosahexaenoyl-phosph...
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Article
Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats
The ethyl ester of eicosapentaenoic acid (EPA) is the only pure EPA-containing lipid available in bulk for oral administration. However, there is doubt as to whether EPA ethyl ester can efficiently increase th...