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Article
Open AccessA risk-based subgroup analysis of the effect of adjuvant S-1 in estrogen receptor-positive, HER2-negative early breast cancer
The Phase III POTENT trial demonstrated the efficacy of adding S-1 to adjuvant endocrine therapy for estrogen receptor-positive, HER2-negative early breast cancer. We investigated the efficacy of S-1 across di...
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Article
De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling
Estrogen receptor (ER) expression in breast cancer can change during progression and the treatment, but the mechanism has not been well studied. In this study, we successfully prepared organoids from samples o...
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Article
Reproducibility assessment of uptake on dedicated breast PET for noise discrimination
Dedicated breast PET (dbPET) systems have improved the detection of small breast cancers but have increased false-positive diagnoses due to an increased chance of noise detection. This study examined whether r...
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Chapter
Identification of Sentinel Lymph Nodes in Breast Cancer Surgery
The safety and usefulness of sentinel node biopsy have been established as a standard treatment for breast cancer. In Japan, the indocyanine green (ICG) fluorescence method has been developed as an alternative...
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Article
Effectiveness of eribulin as first-line or second-line chemotherapy for HER2-negative hormone-resistant advanced or metastatic breast cancer: findings from the multi-institutional, prospective, observational KBCRN A001: E-SPEC study
The optimal positioning of eribulin treatment remains unclear. This study aimed to investigate the effectiveness of eribulin administration as first- and second-line chemotherapy in patients with endocrine-res...
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Article
Open AccessPrognostic significance of PD-L1-positive cancer-associated fibroblasts in patients with triple-negative breast cancer
Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), whic...
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Article
Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity
Among several mechanisms for the resistance of human epidermal growth factor receptor 2-overexpressing (HER2 +) cancer cells to trastuzumab, little is known regarding the mechanism underlying the resistance to...
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Article
Open AccessDirect comparison of magnetic resonance imaging and pathological shrinkage patterns of triple-negative breast cancer after neoadjuvant chemotherapy
We aimed to investigate the usefulness of magnetic resonance imaging (MRI) and histopathological shrinkage patterns to formulate a predictive equation for estimating residual tumor size after neoadjuvant chemo...
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Article
Multispectral quantitative immunohistochemical analysis of tumor-infiltrating lymphocytes in relation to programmed death-ligand 1 expression in triple-negative breast cancer
Programmed death-ligand 1 (PD-L1) expression on immune cells (ICs) is a predictive marker for PD-L1 checkpoint blockade in patients with triple-negative breast cancer (TNBC). However, the level of PD-L1 expres...
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Article
Correction to: Histological classification of breast tumors in the General Rules for Clinical and Pathological Recording of Breast Cancer (18th edition)
In the original publication of the article, the author group and acknowledgements were published incorrectly.
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Article
Open AccessOvarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: a multicenter retrospective cohort study
We previously reported that tamoxifen (TAM)-induced ovarian hyperstimulation (OHS) is associated with high serum concentrations of estradiol in premenopausal women with breast cancer. To investigate risk facto...
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Article
Impact of physiological hormonal fluctuations on 18F-fluorodeoxyglucose uptake in breast cancer
Premenopausal physiologic steroid levels change cyclically, in contrast to steady state low levels seen in postmenopausal patients. The purpose of this study was to evaluate whether 18F-fluorodeoxyglucose (18F-FD...
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Article
Open AccessAnti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug
Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, ...
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Article
Patterns of clinical practice for sentinel lymph node biopsy in women with node-negative breast cancer: the results of a national survey in Japan
Sentinel lymph node (SLN) biopsy is now accepted as the standard of care for axillary staging in women with node-negative breast cancer. Currently, dye, radioisotope (RI), and fluorescence indocyanine green (f...
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Article
Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis
Sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence is safe and has a high detection rate for SLNs. However, the results of this novel technique are heterogeneous. The objective of this...
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Article
Antitumor immunity and advances in cancer immunotherapy
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Article
Advances in personalized cancer immunotherapy
There are currently three major approaches to T cell-based cancer immunotherapy, namely, active vaccination, adoptive cell transfer therapy and immune checkpoint blockade. Recently, this latter approach has de...
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Article
Assessment of the Ki67 labeling index: a Japanese validation ring study
A lack of consistent methods to evaluate Ki67 expression is problematic in terms of accurately predicting prognosis in breast cancer. Accordingly, this study aimed to identify the causes of discrepancies in Ki...
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Chapter
A Perspective on Current Status and Future Directions of Sentinel Node Biopsy Using Fluorescence Imaging System in Breast Cancer
Near-infrared (NIR) imaging using indocyanine green (ICG) fluorescence can localize sentinel lymph node (SLN) in context with lymphatic flows and leads to navigation surgery to identify SLN at high detection r...
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Chapter
Lymphatic Map** and Optimization of Sentinel Lymph Node Dissection
Sentinel lymph node (SLN) biopsy is a standard of care for axillary staging in breast cancer. The modalities involving radioisotope (RI) and blue dye are the most widely used for SLN map**. Near-infrared flu...
