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Article
Open AccessOpportunities arising from the COVID-19: an international orthopaedic surgeons’ perspective
The unprecedented COVID-19 experience has posed severe challenges to the health care system and several of these are documented in orthopaedic surgery; however, although the pandemic has also brought positive ...
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Article
Open AccessPublisher Correction: Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells
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Article
Open AccessOsmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells
Biophysical cues such as osmotic pressure modulate proliferation and growth arrest of bacteria, yeast cells and seeds. In tissues, osmotic regulation takes place through blood and lymphatic capillaries and, at...
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Article
Open AccessSurfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics
Microfluidic production of giant lipid vesicles presents a paradigm-shift in the development of artificial cells. While production is high-throughput and the lipid vesicles are mono-disperse compared to bulk m...
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Article
A machine learning model for predicting risk of hospital readmission within 30 days of discharge: validated with LACE index and patient at risk of hospital readmission (PARR) model
The objective of this study was to design and develop a predictive model for 30-day risk of hospital readmission using machine learning techniques. The proposed predictive model was then validated with the two...
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Article
Open AccessPost-metamorphic carry-over effects of altered thyroid hormone level and developmental temperature: physiological plasticity and body condition at two life stages in Rana temporaria
Environmental stress induced by natural and anthropogenic processes including climate change may threaten the productivity of species and persistence of populations. Ectotherms can potentially cope with stress...
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Article
Open AccessInteraction of SNARE Mimetic Peptides with Lipid bilayers: Effects of Secondary Structure, Bilayer Composition and Lipid Anchoring
The coiled-coil forming peptides ‘K’ enriched in lysine and ‘E’ enriched in glutamic acid have been used as a minimal SNARE mimetic system for membrane fusion. Here we describe atomistic molecular dynamics simula...
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Introduction to the Gorkha Earthquake
This chapter is the introduction to the book and briefly describes the Gorkha earthquake and its impact on Nepal. Progress since the 1950s and the political changes since the 1990s, including the Maoist-led in...
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Chapter
Microfluidic Technology for Molecular Diagnostics
Molecular diagnostics have helped to improve the lives of millions of patients worldwide by allowing clinicians to diagnose patients earlier as well as providing better ongoing therapies. Point-of-care (POC) t...
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Article
Open AccessControlling hypertension immediately post stroke: a cost utility analysis of a pilot randomised controlled trial
Elevated blood pressure (BP) levels are common following acute stroke. However, there is considerable uncertainty if and when antihypertensive therapy should be initiated.
