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Article
Open AccessNon-invasive quantification of stem cell-derived islet graft size and composition
Stem cell-derived islets (SC-islets) are being used as cell replacement therapy for insulin-dependent diabetes. Non-invasive long-term monitoring methods for SC-islet grafts, which are needed to detect misguid...
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Article
Open AccessRFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7 is significantly enriched in the Finnish population, with almost 1:250 individu...
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Modelling of Beta Cell Pathophysiology Using Stem Cell-Derived Islets
Diabetes mellitus is a family of metabolic disorders that arise from the loss or dysfunction of insulin secreting pancreatic beta cells. Many forms of early onset diabetes are caused by monogenic mutations in ...
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Article
Open AccessThe type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical rol...
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Article
Open AccessFunctional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detaile...
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Article
Open AccessMaturation of beta cells: lessons from in vivo and in vitro models
The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily im...
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Article
SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
Congenital hyperinsulinism caused by mutations in the KATP-channel-encoding genes (KATPHI) is a potentially life-threatening disorder of the pancreatic beta cells. No optimal medical treatment is available for pa...