6 Result(s)
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Article
Open AccessExperimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route
Several animal models are used to study influenza viruses. Intranasal inoculation of animals with a liquid inoculum is one of the main methods used to experimentally infect animals with influenza virus; howeve...
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Open AccessAmino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts
We tested the biological significance of two amino acid mutations in the PB2 protein (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9) viruses for mammalian a...
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Characterization of H7N9 influenza A viruses isolated from humans
Here, biological attributes of two early human isolates of the newly emerged H7N9 influenza viruses are characterized: the potential of these viruses to infect and/or transmit within various animal models is d...
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Article
Open AccessExperimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus.
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Article
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe diseas...
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Article
Drosophila RNAi screen identifies host genes important for influenza virus replication
Although several alternative antivirals are available for the treatment of influenza virus infection, the risk that viruses resistant to these drugs will emerge means it is important to continue the search for...
