-
Article
Open AccessThbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production. Here we show that Thbs1...
-
Article
Open AccessThrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enha...
-
Article
Open AccessBEX1 is an RNA-dependent mediator of cardiomyopathy
Regulation of mRNA splicing, processing and stability is increasingly recognized as a critical control point in dynamically altering gene expression during stress or disease. Very little is understood of this ...
-
Article
Open AccessMitsugumin 29 regulates t-tubule architecture in the failing heart
Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that facilitate the synchronous release of Ca2+ from internal stores and subsequent myofilament contraction, although...
-
Article
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18
The cytokine TNF-α, typically considered to have deleterious effects on the heart, can also have cardioprotective effects by inducing formation of a keratin cytoskeletal network in cardiomyocytes.
