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Article
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila
The sense of taste is an important sentinel governing what should or should not be ingested by an animal, with high pH sensation playing a critical role in food selection. Here we explore the molecular identit...
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Article
Open AccessMolecular and cellular basis of acid taste sensation in Drosophila
Acid taste, evoked mainly by protons (H+), is a core taste modality for many organisms. The hedonic valence of acid taste is bidirectional: animals prefer slightly but avoid highly acidic foods. However, how anim...
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Article
Open AccessPrecisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
Dosage of key regulators im**e on developmental disorders such as FOXG1 syndrome. Since neither knock-out nor knock-down strategy assures flexible and precise protein abundance control, to study hypomorphic ...
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Article
Open AccessDifferential antiviral immunity to Japanese encephalitis virus in develo** cortical organoids
Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world’s public health yet without a cure. Certain JEV-infected neural cells express a subset of previously i...
