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Article
Psychometric Evaluation of the Emotion Regulation Questionnaire in a Clinical Sample
The factor structure, reliability, and concurrent validity of the Emotion Regulation Questionnaire were evaluated in a large clinical sample (N = 1,294). Confirmatory factor analysis was used to test the previous...
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Article
Direct and Interactive Effects of Personality and Experiencing Changes in Relationships on Symptoms of Internalizing Psychopathology During the COVID-19 Pandemic
The present study examined the prospective direct and interactive effects of personality (neuroticism, extraversion) and experiencing changes in friendships during the pandemic on symptoms of stress, anxiety, ...
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Living Reference Work Entry In depth
Anxiety and Fear-Related Disorders: Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is an emotional disorder characterized by excessive and difficult-to-control worry about daily events and activities such as work/school, finances, minor matters, community a...
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Article
A general method to optimize and functionalize red-shifted rhodamine dyes
Expanding the palette of fluorescent dyes is vital to push the frontier of biological imaging. Although rhodamine dyes remain the premier type of small-molecule fluorophore owing to their bioavailability and b...
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Article
The Impact of Self-Reported Depression Severity and Age on Facial Emotion Recognition in Outpatients with Anxiety and Mood Disorders
In non-clinical community samples, older adults are less accurate at identifying others’ emotional expressions than younger adults. Less is known about the effects of age on facial emotion recognition (ER) in ...
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Article
A Double-Blind Placebo Controlled Study of Intranasal Oxytocin’s Effect on Emotion Recognition and Visual Attention in Outpatients with Emotional Disorders
The current study used double-blind, placebo-controlled design to examine the effect of intranasal oxytocin (OT) on emotion recognition (ER) and visual attention in 60 outpatients presenting for assessment and...
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Article
Expression of Generalized Anxiety Disorder Across the Lifespan
In generalized anxiety disorder (GAD), both the associated symptoms and worry content have been shown to vary as a function of age (Jeste et al. Biological Psychiatry, 58, 265–271, 2005; Portman et al. Psychiatri...
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Article
The Contribution of Worry Behaviors to the Diagnosis of Generalized Anxiety Disorder
Worry behaviors (i.e., overt acts to avoid or cope with worry-induced distress) have been recognized as being important in the psychopathology and treatment of generalized anxiety disorder (GAD). This study ev...
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Article
Open AccessImproved methods for marking active neuron populations
Marking functionally distinct neuronal ensembles with high spatiotemporal resolution is a key challenge in systems neuroscience. We recently introduced CaMPARI, an engineered fluorescent protein whose green-to...
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Article
A general method to fine-tune fluorophores for live-cell and in vivo imaging
Guidelines for fine-tuning spectral and chemical properties of fluorophore are introduced, resulting in four new Janelia Fluor dyes, JF503, JF525, JF585 and JF635, that span the visible region and align well with...
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Article
Psychometric Properties of the Generalized Anxiety Disorder Scale-7 (GAD-7) in Outpatients with Anxiety and Mood Disorders
This study examined the psychometric properties of the Generalized Anxiety Disorder Scale-7 (GAD-7) in a sample of 536 outpatients presenting at a specialty clinic for anxiety and mood disorders. A confirmator...
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Protocol
Synthesis of Janelia Fluor HaloTag and SNAP-Tag Ligands and Their Use in Cellular Imaging Experiments
The development of genetically encoded self-labeling protein tags such as the HaloTag and SNAP-tag has expanded the utility of chemical dyes in microscopy. Intracellular labeling using these systems requires s...
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Article
Bright photoactivatable fluorophores for single-molecule imaging
Photoactivatable derivatives of the bright and photostable Janelia Fluor dyes enable improved multicolor single-particle tracking and facile localization microscopy in cells.
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Article
High-density three-dimensional localization microscopy across large volumes
Lattice light-sheet and PAINT microscopy are combined to achieve low-background detection of dense molecular labels, yielding super-resolution localization microscopy images of intricate 3D structures within d...
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Article
Perceived Emotion Control Moderates the Relationship Between Neuroticism and Generalized Anxiety Disorder
The relationships between neuroticism, perceived emotion control, and generalized anxiety disorder (GAD) severity were examined in 293 individuals diagnosed with GAD at a specialty anxiety disorders clinic. Hi...
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Article
Bayesian Analysis of Current and Lifetime Comorbidity Rates of Mood and Anxiety Disorders in Individuals with Posttraumatic Stress Disorder
Although posttraumatic stress disorder (PTSD) is no longer considered an anxiety disorder in DSM-5, previous research has indicated high rates of comorbid anxiety and mood disorders in individuals with PTSD. The ...
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Article
Differential Item Functioning of the Symptoms of Major Depression by Race and Ethnicity: An Item Response Theory Analysis
This study examines the psychometric properties, and particularly differential item functioning (DIF) due to racial and ethnic group, of the criteria for a major depressive episode using a large sample (N = 1,063...
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Article
Assessing Squalor in Hoarding: The Home Environment Index
The current study examined a new measure of squalor associated with hoarding, the Home Environment Index (HEI). Participants (N = 793) were recruited from a large database of individuals who sought information ab...
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Article
Perceived Control is a Transdiagnostic Predictor of Cognitive–Behavior Therapy Outcome for Anxiety Disorders
Perceived control has been proposed to be a general psychological vulnerability factor that confers an elevated risk for develo** anxiety disorders, but there is limited research examining perceived control...
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Article
The Relevance of Age of Onset to the Psychopathology of Social Phobia
The present study aimed to examine the relevance of age of onset to the psychopathology of social phobia using a large clinical sample of 210 patients with social phobia. The two most common periods of onset w...
