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High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

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  1. Article

    Open Access

    Aortic elastic fiber degeneration during acute type a aortic dissection and reverse aortic remodeling

    Progression of proximal or distal aortic dilatation is defined as reverse aortic remodeling after surgery for acute type A aortic dissection (ATAAD) that may be dependent on aortic wall degeneration.

    Trina Chen, Ivana Kholova, Timo Paavonen in Journal of Cardiothoracic Surgery (2024)

  2. Article

    Open Access

    Histopathology reveals concealed aortic valve inflammation

    The extent of aortic valve inflammation in patients undergoing aortic valve replacement (AVR) is unsettled. The significance of aortic valve histopathology in patients undergoing AVR is undetermined.

    Mona Laaksonen, Ivana Kholova, Timo Paavonen in Journal of Cardiothoracic Surgery (2024)

  3. Article

    Open Access

    Ascending aortic wall degeneration in patients with bicuspid versus tricuspid aortic valve

    The magnitude of ascending aortic degeneration in patients with bicuspid aortic valves (BAV) is controversial.

    Ari Mennander, Ivana Kholova, Saku Pelttari in Journal of Cardiothoracic Surgery (2022)

  4. Article

    Open Access

    Evaluation Challenges in the Validation of B7-H3 as Oral Tongue Cancer Prognosticator

    B7-H3 was the only molecule identified with prognostic potential from a recent systematic review of the prognostic value of immune checkpoints in oral cancer. We aimed to validate this finding in a multicenter...

    Meri Sieviläinen, Anna Maria Wirsing, Aini Hyytiäinen in Head and Neck Pathology (2021)

  5. Article

    Open Access

    Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

    Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting...

    Toni Grönroos, Artturi Mäkinen, Saara Laukkanen, Juha Mehtonen in Scientific Reports (2020)

  6. Article

    Open Access

    Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

    Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be...

    Tiina Vesterinen, Kaisa Salmenkivi, Harri Mustonen, Teijo Kuopio in Virchows Archiv (2020)

  7. Article

    Open Access

    Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency

    We studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA) components in adenine-induced chronic renal insufficiency (CRI).

    Suvi Törmänen, Ilkka Pörsti, Päivi Lakkisto, Ilkka Tikkanen, Onni Niemelä in BMC Nephrology (2017)

  8. Article

    Open Access

    Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms

    Few data are available about the inflammatory cytokine profile of bronchoalveolar lavage (BAL) from young children with frequent wheeze. The first aim was to investigate the BAL cellular and cytokine profiles ...

    Kristiina Malmström, Maili Lehto, Marja-Leena Majuri in Clinical and Translational Allergy (2014)

  9. Article

    Open Access

    Polysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas

    The aim of the study was to assess the localization of Polysialic acid (polySia) and Neural cell adhesion molecule (NCAM) in grade I–IV astrocytomas by confocal microscopy, and also to clarify and compare thei...

    Katri Mäkelä, Kristiina Nordfors, Jukka Finne, Anne Jokilammi, Timo Paavonen in BMC Cancer (2014)

  10. Article

    Open Access

    Complement activation in astrocytomas: deposition of C4d and patient outcome

    C4d is a cleavage product of complement component C4 and is considered to serve as a marker for the site of complement activation. In this study C4d staining of grade I-IV astrocytic tumors was studied to expl...

    Katri Mäkelä, Pauli Helén, Hannu Haapasalo, Timo Paavonen in BMC Cancer (2012)

  11. Article

    Open Access

    Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study

    Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated.

    Annika Luukkainen, Jussi Karjalainen, Teemu Honkanen in Clinical and Translational Allergy (2011)