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Open AccessCenter-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin o...
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Article
Open AccessSuppression without inhibition: how retinal computation contributes to saccadic suppression
Visual perception remains stable across saccadic eye movements, despite the concurrent strongly disruptive visual flow. This stability is partially associated with a reduction in visual sensitivity, known as s...
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Article
Open AccessMinimal genetically encoded tags for fluorescent protein labeling in living neurons
Modern light microscopy, including super-resolution techniques, has brought about a demand for small labeling tags that bring the fluorophore closer to the target. This challenge can be addressed by labeling u...
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Article
Open AccessNeural circuits in the mouse retina support color vision in the upper visual field
Color vision is essential for an animal’s survival. It starts in the retina, where signals from different photoreceptor types are locally compared by neural circuits. Mice, like most mammals, are dichromatic w...
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Open AccessType-specific dendritic integration in mouse retinal ganglion cells
Neural computation relies on the integration of synaptic inputs across a neuron’s dendritic arbour. However, it is far from understood how different cell types tune this process to establish cell-type specific...
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Open AccessThe temporal structure of the inner retina at a single glance
The retina decomposes visual stimuli into parallel channels that encode different features of the visual environment. Central to this computation is the synaptic processing in a dense layer of neuropil, the so...
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Open AccessA retinal model of cerebral malaria
Malaria is a causative factor in about 500.000 deaths each year world-wide. Cerebral malaria is a particularly severe complication of this disease and thus associated with an exceedingly high mortality. Malari...
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Inhibition decorrelates visual feature representations in the inner retina
The retina extracts visual features for transmission to the brain. Different types of bipolar cell split the photoreceptor input into parallel channels and provide the excitatory drive for downstream visual ci...
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Open AccessDeletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype
The unconventional myosin VI, a member of the actin-based motor protein family of myosins, is expressed in the retina. Its deletion was previously shown to reduce amplitudes of the a- and b-waves of the electr...
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Retinal bipolar cells: elementary building blocks of vision
Bipolar cells are the only neurons that connect the outer retina to the inner retina. They implement an 'extra' layer of processing that is not typically found...
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Open AccessAssembly of the outer retina in the absence of GABA synthesis in horizontal cells
The inhibitory neurotransmitter gamma-amino-butyric acid (GABA) not only modulates excitability in the mature nervous system but also regulates neuronal differentiation and circuit development. Horizontal cell...
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Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions
Tiling describes the arrangement of neuronal processes in a pattern with little or no overlap with those of neighboring neurons. It is unclear how this is mediated in the vertebrate retina, whose mosaic cell b...
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Open AccessDevelopmental patterning of glutamatergic synapses onto retinal ganglion cells
Neurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attaine...
