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Article
Open AccessMyelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Axonal degeneration determines the clinical outcome of multiple sclerosis and is thought to result from exposure of denuded axons to immune-mediated damage. Therefore, myelin is widely considered to be a prote...
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Article
Open AccessIron concentrations in neurons and glial cells with estimates on ferritin concentrations
Brain iron is an essential as well as a toxic redox active element. Physiological levels are not uniform among the different cell types. Besides the availability of quantitative methods, the knowledge about th...
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Article
Open AccessIon exchanger in the brain: Quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties
Perineuronal nets (PNs) are a specialized form of brain extracellular matrix, consisting of negatively charged glycosaminoglycans, glycoproteins and proteoglycans in the direct microenvironment of neurons. Sti...
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Article
Solid State Analysis with the New Leipzig High-Energy Ion Nanoprobe
The high-energy ion nanoprobe LIPSION at the University of Leipzig has been operational since October 1998. The ultrastable single ended 3.5 MV SINLETRONTM accelerator supplies the H+ or He+ ion beam. A magnetic...