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  1. Article

    Open Access

    Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion

    Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organell...

    Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong… in Nature Communications (2023)

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