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    Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation

    The human pathogen Pseudomonas aeruginosa can easily form biofilms. The extracellular matrix produced by the bacterial cells acts as a physical barrier to hinder the antibiotics treatment. It is necessary to dest...

    Tianhu Zhao, Jian Zhang, Maomao Tang, Luyan Z. Ma in The Journal of Antibiotics (2019)

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    PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

    Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and prot...

    Shan Yu, Tiantian Su, Huijun Wu, Shiheng Liu, Di Wang, Tianhu Zhao in Cell Research (2015)