-
Article
Open AccessAberrant splicing of CaV1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia
Diabetic hyperglycemia induces dysfunctions of arterial smooth muscle, leading to diabetic vascular complications. The CaV1.2 calcium channel is one primary pathway for Ca2+ influx, which initiates vasoconstricti...
-
Article
HOXD9 is a potential prognostic biomarker involved in immune microenvironment of glioma
Glioma is the prevailing malignant tumor affecting the brain and central nervous system, constituting over 80% of all malignant brain tumors. HOXD9 has been implicated in the development of glioma, but the spe...
-
Article
Open AccessDysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy
L-type Ca2+ channel CaV1.2 is essential for cardiomyocyte excitation, contraction and gene transcription in the heart, and abnormal functions of cardiac CaV1.2 channels are presented in diabetic cardiomyopathy. H...
-
Article
Open AccessA predictive model for postoperative progressive haemorrhagic injury in traumatic brain injuries
Progressive haemorrhagic injury after surgery in patients with traumatic brain injury often results in poor patient outcomes. This study aimed to develop and validate a practical predictive tool that can relia...
-
Article
Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice
Rabies remains a public health threat that kills approximately 59,000 people worldwide each year, most of which are from the develo** countries of Africa and Asia where dog rabies are endemic. Therefore, dev...
