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Article
Open AccessPANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in contr...
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Article
Altered intra- and inter-network brain functional connectivity associated with prolonged screen time in pre-school children with autism spectrum disorder
Prolonged screen time (ST) has adverse effects on autistic characteristics and language development. However, the mechanisms underlying the effects of prolonged ST on the neurodevelopment of children with auti...
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Article
Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation
Acute pancreatitis (AP) is an inflammatory disease of the exocrine pancreas. Disruptions in organelle homeostasis, including macroautophagy/autophagy dysfunction and endoplasmic reticulum (ER) stress, have bee...
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Article
Glucagon-Like Peptide 1 Receptor Agonists in Alzheimer’s Disease
Glucagon-like peptide-1 receptor agonist (GLP-1RA)has been found to have a complex and extensive connection with Alzheimer’s disease (AD). The study is to further determine the therapeutic effect of GLP-1RA on...
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Article
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis
Acute kidney injury (AKI) refers to a group of common clinical syndromes characterized by acute renal dysfunction, which may lead to chronic kidney disease (CKD), and this process is called the AKI-CKD transit...
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Article
Open AccessDeeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology
With the incidence of hypertension increasing worldwide, more and more the mechanisms of hypertension from the perspective of immunity have found. Intestinal microbiota as well as its metabolites relationship ...
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Article
Long Slimmer Metal Stent Is Feasible and Effective for Endoscopic Dual Stent-by-Stent Placement in Malignant Hilar Biliary Stricture
Bilateral endoscopic biliary stenting remains technically challenging, which limits its wider clinical application.
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Article
SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis
Many molecular alterations are shared by embryonic liver development and hepatocellular carcinoma (HCC). Identifying the common molecular events would provide a novel prognostic biomarker and therapeutic targe...
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Article
Open AccessIdentification and validation of a novel glycolysis-related gene signature for predicting the prognosis in ovarian cancer
Ovarian cancer (OC) is the most lethal gynaecological tumor. Changes in glycolysis have been proven to play an important role in OC progression. We aimed to identify a novel glycolysis-related gene signature t...
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Article
Differential conductance and spin current in hybrid quantum dot-topological superconducting nanowire
Majorana bound states (MBSs) are topologically protected and follow the non-abelian rather than the usual Fermi–Dirac statistical rule, and then are ideal choice for the preparation of quantum bits in topologi...
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Article
Internal layering structure and subglacial conditions along a traverse line from Zhongshan Station to Dome A, East Antarctica, revealed by ground-based radar sounding
During the 21st Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05), a radar dataset was collected using a ground-based radar system, along a traverse line from Zhongshan Station to DT401 (130...
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Article
Initial Experience of ERCP-Guided Radiofrequency Ablation as the Primary Therapy for Inoperable Ampullary Carcinomas
Endoscopic ablation of duodenal ampullary malignancy has not been fully assessed.
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Article
Effects of energy deposition on mechanical properties of sodium borosilicate glass irradiated by three heavy ions: P, Kr, and Xe
Sodium borosilicate glasses are candidate materials for high-level radioactive waste vitrification; therefore, understanding the irradiation effects in model borosilicate glass is crucial. Effects of electroni...
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Article
Boc-phenylalanine Grafted Poly(3,4-propylenedioxythiophene) Film for Electrochemically Chiral Recognition of 3,4-Dihydroxyphenylalanine Enantiomers
To prepare chiral monomer with single chiral center and higher stereospecificity, a pair of amino-functionalized chiral 3,4-propylenedioxythiophene (ProDOT) derivatives, chiral (3,4-dihydro-2H-thieno[3,4-b][1,4]d...
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Article
Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor
Oncofetal genes are genes that express abundantly in both fetal and tumor tissues yet downregulated or undetected in adult tissues, and can be used as tumor markers for cancer diagnosis and treatment. Meanwhil...
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Article
Test case selection using multi-criteria optimization for effective fault localization
As spectra-based fault localization techniques report suspicious statements by analyzing the coverage of test cases, the effectiveness of the results is highly dependent on the composition of test suites. This...
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Article
Identification and characterization of a chondroitin synthase from Avibacterium paragallinarum
Avibacterium paragallinarum is a Gram-negative bacterium that causes infectious coryza in chicken. It was reported that the capsule polysaccharides extracted from Av. paragallinarum genotype A contained chondroit...
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Article
A New Fully Covered Self-Expandable Metal Stent for the Treatment of Postsurgical Benign Biliary Strictures
Endotherapy with plastic stent (PS) placement is the main modality for treating benign biliary strictures (BBSs). Fully covered self-expandable metal stents (FCSEMSs) are being increasingly used for BBS manage...
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Article
The direct analysis of drug distribution of rotigotine-loaded microspheres from tissue sections by LESA coupled with tandem mass spectrometry
The direct analysis of drug distribution of rotigotine-loaded microspheres (RoMS) from tissue sections by liquid extraction surface analysis (LESA) coupled with tandem mass spectrometry (MS/MS) was demonstrate...
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Article
The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1
Understanding the roles of splicing factors and splicing events during tumorigenesis would open new avenues for targeted therapies. Here we identify an oncofetal splicing factor, MBNL3, which promotes tumorige...
