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Article
Open AccessChromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis
Rhododendron molle (Ericaceae) is a traditional Chinese medicine, which has been used to treat rheumatism and relieve pain since ancient times. The characteristic grayanoids of this plant have been demonstrated ...
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Article
High-level soluble expression of human Cu,Zn superoxide dismutase with high activity in Escherichia coli
As the most important member of antioxidant defense system, human Cu,Zn superoxide dismutase (hCu,Zn-SOD) protects cells against the free radicals produced by aerobic metabolism. hCu,Zn-SOD has been widely use...
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Article
Open AccessStructures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition
LXYL-P1-2 is one of the few xylosidases that efficiently catalyze the reaction from 7-β-xylosyl-10-deacetyltaxol (XDT) to 10-deacetyltaxol (DT), and is a potential enzyme used in Taxol industrial production. H...
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Article
Open AccessCorrection: Author Correction: Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
Nature Communications 8: Article number: 15544 (2017); Published: 18 May 2017, Updated: 13 July 2018 In the originally published version of this Article, financial support was not fully acknowledged. The PDF a...
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Article
Open AccessImproving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10-deacetyltaxol is up to 0.5%. While this compound is not an intermediate in Taxol ...
