5,911 Result(s)
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Tian-** Zhang
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Article
Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Open AccessLASSO-derived nomogram for early identification of pediatric monogenic lupus
Monogenic lupus is defined as systemic lupus erythematosus (SLE)/SLE-like patients with either dominantly or recessively inherited pathogenic variants in a single gene with high penetrance. However, because th...
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Open AccessMaternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study
Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases...
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Correction to: Association Between a Failed Prominence Eruption and the Drainage of Mass from Another Prominence
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Open AccessEstablishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq
Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its late diagnosis, high therapeutic resistance, and a dearth of ...
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Open AccessA rapid aureochrome opto-switch enables diatom acclimation to dynamic light
Diatoms often outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The identities and operational mechanisms of regulato...
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Open AccessA privacy-preserving image retrieval scheme with access control based on searchable encryption in media cloud
With the popularity of the media cloud computing industry, individuals and organizations outsource image computation and storage to the media cloud server to reduce the storage burden. Media images usually con...
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Open AccessEfficacy of MAGE-A4 long peptide as a universal immunoprevention cancer vaccine
The clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently subject to certain limitations in clinical trials, including the challe...
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Open AccessNeoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This...
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Open AccessRetrospective analysis of reference intervals for dried blood spot based ms/ms newborn screening programs in Chinese preterm neonates: a nationwide study
Although recent discoveries regarding the biomarkers of newborn screening (NBS) programs by tandem mass spectrometry (MS/MS) highlight the critical need to establish reference intervals (RIs) specifically for ...
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Novel PATL2 variants cause female infertility with oocyte maturation defect
Oocyte maturation defect (OOMD) is a rare cause of in vitro fertilization failure characterized by the production of immature oocytes. Compound heterozygous or homozygous PATL2 mutations have been associated with...
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Open AccessSirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water and are the only herbivorous marine mammals. Here, we generated a chromosome-level dugong (Dugong dugon) genome. A co...
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Open AccessAn optimal combination of four active components in Huangqin decoction for the synergistic sensitization of irinotecan against colorectal cancer
Irinotecan (CPT-11) is a first-line treatment for advanced colorectal cancer (CRC). Four components (baicalin, baicalein, wogonin, and glycyrrhizic acid) derived from Huangqin Decoction (HQD) have been proven ...
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Open AccessThe Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been previously shown to promote excitatory synaptic transmission and n...
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PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury
Synchronized ferroptosis contributes to nephron loss in acute kidney injury (AKI). However, the propagation signals and the underlying mechanisms of the synchronized ferroptosis for renal tubular injury remain...
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Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
The purpose of this study is to explore the shared molecular pathogenesis of traumatic brain injury (TBI) and high-grade glioma and investigate the mechanism of propofol (PF) as a potential protective agent. B...
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Novel Synthesis of CuW Composite Containing Micro- and Nano-tungsten Particles Coated with SixWy Phase via Silicothermic Coupling with Aluminothermic Reduction
A novel method for preparing CuW composite containing micro- and nano-tungsten particles coated with SixWy phase via silicothermic coupling with aluminothermic reduction is presented in this paper. Compared with ...
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Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expressed in major dopaminergic areas and plays a crucial role in modulation of central dopamin...
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Solar-driven photothermal catalytic CO2 conversion: a review
It is highly desirable to seek green and sustainable technologies, such as employing photothermal effects to drive energy catalysis processes to address the high energy demand and associated environmental impa...
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Dominant 1/3-filling correlated insulator states and orbital geometric frustration in twisted bilayer graphene
Geometric frustration occurs in a lattice system when not all the interactions can be satisfied simultaneously. The simplest example is antiferromagnetically coupled spins on a triangular lattice. Frustrated s...
