5 Result(s)
within
Tiago da Silva Medina
-
Article
Tertiary lymphoid structures as hubs of antitumour immunity
In this Journal Club, Kinker & Medina discuss a study showing the role of tumour-associated tertiary lymphoid structures in improving immunotherapy response and overall survival in patients with melanoma.
-
Article
Open AccessComprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
Gliomas are the most commonly occurring malignant brain tumor characterized by an immunosuppressive microenvironment accompanied by profound epigenetic changes, thus influencing the prognosis. Glutathione pero...
-
Article
Open AccessTargeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for tran...
-
Article
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
The use of liquid biopsies for cancer detection and management is rapidly gaining prominence1. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA,...
-
Article
Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10. Ac...
