5 Result(s)

Article

Partial dechlorination of 2,4,4′-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A2

Isabella Randerath, Natalia Quinete, Julian Peter Müller… in Archives of Toxicology (2024)

Article

Ten years after: findings from the medical surveillance program on Health Effects in High-Level Exposure to PCB (HELPcB)

After the detection of high environmental and occupational exposure to polychlorinated biphenyls (PCBs) in a German recycling company for transformers and capacitors in 2010, the multidisciplinary medical surv...

Jens Rengelshausen, Isabella Randerath, Thomas Schettgen… in Archives of Toxicology (2023)

Article

New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite (“M-12”)

Methylisothiazolinone (MI) as well as the mixture of chloromethylisothiazolinone/methylisothiazolinone [MCI/MI (3:1)] are biocides that are used in a variety of products of every-day life. Due to the skin sens...

Thomas Schettgen, J. Bertram, T. Kraus in Archives of Toxicology (2021)

Article

Longitudinal changes in telomere length in PCB-exposed individuals: interaction with CMV infection

We recently demonstrated a significant shortening of age-adapted telomere length (TL) in lymphocytes of polychlorinated biphenyls (PCB)-exposed individuals. Here, we analyzed TL in individuals of the same PCB-...

Fabian Beier, Andre Esser, Lucia Vankann, Anne Abels… in Archives of Toxicology (2021)

Article

Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure

Polychlorinated biphenyls (PCBs) are organochlorine pollutants with a worldwide dissemination. We examined telomere length (TL) in peripheral blood cells of 207 individuals with a high body burden of PCBs due ...

Susanne Ziegler, Thomas Schettgen, Fabian Beier, Stefan Wilop… in Archives of Toxicology (2017)