![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessTen years after: findings from the medical surveillance program on Health Effects in High-Level Exposure to PCB (HELPcB)
After the detection of high environmental and occupational exposure to polychlorinated biphenyls (PCBs) in a German recycling company for transformers and capacitors in 2010, the multidisciplinary medical surv...
-
Article
Open AccessInfluence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial
The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific eff...
-
Article
Oxycodone Effect on Pupil Constriction in Recreational Opioid Users: A Pharmacokinetic/Pharmacodynamic Meta-Analysis Approach
Understanding the effect of oxycodone pharmacokinetics (PK) on µ-opioid receptor binding benefits from an integrated approach to compiling the results of multiple studies. The current pharmacokinetic/pharmacod...
-
Article
Open AccessHow to Interpret an Investigator’s Brochure for Meaningful Risk Assessment: Results of an AGAH Discussion Forum
A discussion forum was hosted by the Association for Applied Human Pharmacology (AGAH e.V.) to critically debate how to interpret and optimise the Investigator’s Brochure (IB) for meaningful risk assessment of...
-
Article
Open AccessWho is a ‘healthy subject’?—consensus results on pivotal eligibility criteria for clinical trials
A discussion forum was hosted by the German not-for-profit Association for Applied Human Pharmacology (AGAH e.V.) to critically review key eligibility criteria and stop** rules for clinical trials with healt...
-
Article
High absolute bioavailability of methylene blue given as an aqueous oral formulation
Methylene blue (MB) has recently been reevaluated for malaria treatment. With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given a...
-
Article
Open AccessMethylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine
The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover ...
-
Article
Pharmacokinetics of a netilmicin loading dose on the first postnatal day in preterm neonates with very w gestational age
Pharmacokinetic parameters are important for dose adjustment of aminoglycosides, but they are highly variable in neonates. In this study the pharmacokinetics of a netilmicin loading dose was investigated on th...
-
Article
Open AccessSafety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]
Safe, effective and affordable drug combinations against falciparum malaria are urgently needed for the poor populations in malaria endemic countries. Methylene blue (MB) combined with chloroquine (CQ) has bee...
-
Article
Dose individualisation in patients with renal insufficiency: does drug labelling support optimal management?
An important information source for pharmacotherapy in populations at risk is drug labelling. We compared the recommendations for patients with renal insufficiency included in German drug labellings with evide...
-
Article
Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria
The combination of chloroquine and methylene blue is potentially effective for the treatment of chloroquine-resistant malaria caused by Plasmodium falciparum. The aim of this study was to investigate whether met...
-
Article
Familiäres Mittelmeerfieber
Drei türkische Patienten zwischen 23 und 32 Jahren stellten sich mit akuten Abdominalschmerzen und Fieber vor. Bei allen traten seit Jahren diese Beschwerden rezidivierend im Abstand von Wochen auf und sistier...
-
Chapter
Inhibition of Porcine Renal Ecto-ATP Diphosphohydrolase by Ca2+ Channel Blockers and Neuroleptic Drugs
Brush-border membrane vesicles (BBMV) from rat, rabbit and pig kidneys have been used to characterize renal ecto-ATPases. In rat1,2 and rabbit renal BBMV3, Mg2+ stimulated enzyme activity better than Ca2+, wherea...