20 Result(s)

Article

Liver steatosis in pre-transplant liver biopsies can be quantified rapidly and accurately by nuclear magnetic resonance analysis

Donor livers marginally acceptable or acceptable according to extended criteria are more frequently transplanted due to the growing discrepancy between demand and availability of donor organs. One type of marg...

Stefanie Bertram, Cathrin Myland, Sandra Swoboda, Anja Gallinat… in Virchows Archiv (2017)

Article

Optimized outcomes for renal allografts with cold ischemic times of 20 h or greater

Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term out...

Anja Gallinat, Andreas Paul, Thomas Minor… in International Urology and Nephrology (2012)

Article

Polylactide (LTS) causes less inflammation response than polydioxanone (PDS): a meniscus repair model in sheep

Incidence of meniscus injury has increased in today’s active society. Arthroscopical refixation yields better results than partial meniscectomy. The best healing rates are achieved by sutures. As non-degradabl...

Christof Burger, Koroush Kabir… in Archives of Orthopaedic and Trauma Surgery (2006)

Article

Cyclic AMP alleviates endoplasmic stress and programmed cell death induced by lipopolysaccharides in human endothelial cells

The possible protection provided by enhancement of the cAMP signal in the process of lipopolysaccharide (LPS)-induced endothelial cell death has been addressed, with special emphasis on the endoplasmic initiat...

Frank A. Schildberg, Susanne Schulz, Frank Dombrowski… in Cell and Tissue Research (2005)

Article

Kidney transplantation from non-heart-beating donors after oxygenated low-flow machine perfusion preservation with histidine–tryptophan–ketoglutarate solution

The aim of this study was to determine the potential benefit of aerobic machine preservation (MP) with non-colloidal histidine–tryptophan–ketoglutarate (HTK) solution compared with MP with Belzer machine perfu...

Thomas Minor, Mario Sitzia, Frank Dombrowski in Transplant International (2005)

Article

Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model

Improvement of organ procurement from non-heart-beating donors (NHBDs) could increase the donor organ pool for liver transplantation. Whether anti-coagulative and anti-vasospastic substances can improve hepat...

Sven Richter, Jun-ichiro Yamauchi, Thomas Minor… in Transplant International (2000)

Chapter

Gaseous Oxygenation of the Ischemic Rat Liver

The lack of aerobic metabolism during ischemic organ preservation plays a pivotal role in the development of tissue alterations during the storage period and favours the manifestation of reper-fusion injuries,...

Thomas Minor, Brigitte Vollmar, Hiltrud Klauke… in Oxygen Transport to Tissue XX (1998)

Chapter

Influence of Taurine Supplementation on Ischemic Preservation of the Isolated Rat Kidney

Taurine (2-aminoethanesulfonic acid) is an endogenous amino acid with unique functions as a modulator of transmembraneous calcium transport, an osmoregulator and putatively a free radical scavenger^4,7,12.

Christoph Licht, Eckhard Kriegesmann, Thomas Minor, Peter Wingenfeld… in Taurine 3 (1998)

Chapter

A Correlation of Intravital Microscopically Assessed NADH Fluorescence, Tissue Oxygenation, and Organ Function during Shock and Resuscitation of the Rat Liver

Multiple organ failure following severe hemorrhagic shock and trauma continues to be a major problem and accounts for a high mortality rate in surgical intensive care units. Persisting depression of micro vasc...

Brigitte Vollmar, Markus Burkhardt, Thomas Minor… in Oxygen Transport to Tissue XX (1998)

Chapter

Protective Effect of Taurine on Hypoxia and Reoxygenation-Induced Damage of Human Colon Cells (HT 29)

Transplantation of the small and large bowel may eventually become a curative treatment for pediatric and adult patients with intestinal failure and short gut syndrome. Since the first description of human all...

Peter Wingenfeld, Dietrich Volker Michalk, Angela Sonntag, Stefan Paas… in Taurine 2 (1996)

Chapter

Taurine Reduces Experimental Liver Injury after Cold Ischemic Preservation and a Period of Rewarming Prior to Reperfusion

Livers of male Wistar rats (250–300 g) were isolated and flushed with 10 ml of Ringer’s solution and 10 ml of UW preservation solution. Then the organs were stored for 24 h at 4°C in UW solution. Livers of Gro...

Thomas Minor, Tetsuya Yamaguchi, Hiltrud Klauke, Peter Wingenfeld… in Taurine 2 (1996)

Chapter

Long-Lasting Hypoxic Preservation of Porcine Kidney Cells

In the field of transplantation medicine one of the determining factors for the outcome of the transplanted organ is the cellular deterioration due to hypoxia and reoxygenation and the protection against it. F...

Peter Wingenfeld, Ute Gehrmann, Stefan Strübind, Thomas Minor, Wolf Isselhard… in Taurine 2 (1996)

Article

Hypoxic cellular deterioration and its prevention by the amino acid taurine in a transplantation model with renal tubular cells (LLC-PK1)

Peter Wingenfeld, Thomas Minor, Ute Gehrmann… in In Vitro Cellular & Developmental Biology … (1995)

Article

Effects of taurine on liver preservation in UW solution with consecutive ischemic rewarming in the isolated perfused rat liver

Taurine (2-aminoethane sulfonic acid) is a physiologic amino acid involved in cellular osmoregulation in various species including man. This study was intended to compare the respective effects of cold storage...

Thomas Minor, Tetsuya Yamaguchi, Woll Isselhard in Transplant International (1995)

Chapter

Protecting effect of Taurine against Hypoxic Cell Damage in Renal Tubular Cells Cultured in Different Transplant Preservation Solutions

The transplantation of human organs is an important field in current medicine and medical research. One of the limiting steps in organ transplantation is the preservation of the graft. Frequently the hypoxic s...

Peter Wingenfeld, Stefan Strübind, Ute Gehrmann… in Taurine in Health and Disease (1994)

Article

The effects of allopurinol and SOD on lipid peroxidation and energy metabolism in the liver after ischemia in an aerobic/anaerobic persufflation

This study was aimed at examining the vulnerability of the liver to oxygen-free radicals upon reoxygenation after prolonged ischemia. Livers from male Wistar rats were first flushed with Ringer's and Euro-Coll...

Thomas Minor, Wolf Isselhard, Yuzo Yamamoto, Mitsuhiro Obara, Stefan Saad in Surgery Today (1993)

Article

Local Positive Behavioral Contrast in the Rat

After baseline training on a multiple variable interval/variable interval schedule, three rats were shifted to multiple extinction/variable interval in Phase 2, and back to multiple variable interval/variable ...

Arthur Gutman, Thomas Minor in The Psychological Record (1976)