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Article
Arachidonic Acid Binds 14-3-3ζ, Releases 14-3-3ζ from Phosphorylated BAD and Induces Aggregation of 14-3-3ζ
Polyunsaturated fatty acids, like arachidonic acid, can bind proteins and affect their function. The 14-3-3 proteins bind phosphorylated sites on a diverse array of client proteins and, in this way, are involv...
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Article
Capturing Proteins that Bind Polyunsaturated Fatty Acids: Demonstration Using Arachidonic Acid and Eicosanoids
Polyunsaturated fatty acids (PUFA) and their biological derivatives, including the eicosanoids, have numerous roles in physiology and pathology. Although some eicosanoids are known to act through receptors, th...
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Article
Expression of 5-lipoxygenase in specialized epithelial cells of nasopharyngeal-associated lymphoid tissue
Leukotrienes are lipid mediators that are produced primarily by certain types of leukocytes. The synthesis of the leukotriene LTB4 is initiated by the enzyme 5-lipoxygenase and completed by LTA4 hydrolase. Epithe...
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Article
Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme
Leukotrienes are inflammatory mediators involved in several diseases. The enzyme 5-lipoxygenase initiates the synthesis of leukotrienes from arachidonic acid. Little structural information is available regard...
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Chapter
Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to Lipopolysaccharide
Eicosanoids are a diverse group of intercellular mediators derived from the enzymatic modification of arachidonic acid (AA1). The prostaglandins (PGs) and leukotrienes (LTs) are two major groups of eicosanoids. T...
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Chapter
Nuclear Import of Arachidonate 5-Lipoxygenase
Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the syn...
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Chapter
5-Lipoxygenase and the Nucleus: Where, When, How, and Why?
Only in the last decade has research focused on the intracellular site(s) of leukotriene (LT) synthesis. These studies have revealed an unexpected critical role for the cell nucleus as a site at which 5-lipoxy...
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Chapter
Hormones and the Orientation of Growth
Hormones are chemical messengers which act at target sites to regulate rates and amounts of growth of cells in tissues of roots, stems, leaves, buds, flowers, and fruits. In this chapter, we shall focus on the...
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Article
The role of calcium in growth induced by indole-3-acetic acid and gravity in the leaf-sheath pulvinus of oat (Avena sativa)
Leaf-sheath pulvini of excised segments from oat (Avena sativa L.) were induced to grow by treatment with 10 μM indole-3-acetic acid (IAA), gravistimulation, or both, and the effects of calcium, EGTA, and calcium...
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Article
Biophysical basis of growth promotion in primary leaves ofPhaseolus vulgaris L. by hormones versus light
Rapid cell enlargement in primary leaves of bean is induced by bright white light (WL), gibberellic acid (GA3) or the cytokinin N6-benzyladenine (BA). In previous studies it has been shown that all three agents c...
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Article
Role of acid efflux during growth promotion of primary leaves of Phaseolus vulgaris L. by hormones and light
The white-light-(WL) induced enlargement of dicotyledonous leaf cells is known to occur via an acid-growth mechanism; i.e., WL causes leaf cells to excrete protons which lead to an increase in wall extensibili...
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Article
A new member of the CAB gene family: structure, expression and chromosomal location of Cab-8, the tomato gene encoding the Type III chlorophyll a/b-binding polypeptide of photosystem I
We have previously reported the isolation and characterization of tomato nuclear genes encoding two types of chlorophyll a/b-binding (CAB) polypeptides localized in photosystem (PS) I and two types of CAB poly...
