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Article
Open AccessBest practices for the management of febrile seizures in children
Febrile seizures (FS) are commonly perceived by healthcare professionals as a self-limited condition with a generally ‘benign’ nature. Nonetheless, they frequently lead to pediatric consultations, and their ma...
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Article
Open AccessKIRREL3-related disorders: a case report confirming the radiological features and expanding the clinical spectrum to a less severe phenotype
Neurodevelopmental disorders have a multifactorial etiology, since biological, genetic, psychosocial and environmental risk factors are involved. Recent studies have been linking neurodevelopmental disorders a...
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Article
Specifications and validation of the ACMG/AMP criteria for clinical interpretation of sequence variants in collagen genes associated with joint hypermobility
Deleterious variants in collagen genes are the most common cause of hereditary connective tissue disorders (HCTD). Adaptations of the American College of Medical Genetics and Genomics/Association for Molecular...
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Article
Cell-based assays for the detection of MOG antibodies: a comparative study
The detection of antibodies to myelin oligodendrocyte glycoprotein (MOG) is fundamental for the identification of MOG antibody-associated disorders (MOGAD), and the differential diagnosis of acquired demyelina...
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Article
Cough Remedies for Children and Adolescents: Current and Future Perspectives
Cough is a widespread symptom in children and adolescents. Despite advances in scientific knowledge about the neurophysiological mechanisms underlying the cough reflex, the best therapeutic approaches for chil...
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Open AccessAbdominal pain as first manifestation of lyme neuroborreliosis in children, case report and review of literature
Lyme neuroborreliosis can cause a variety of neurological manifestations. European children usually present facial nerve palsy, other cranial nerve palsies and aseptic meningitis.
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Article
Open AccessPai syndrome: a review
Pai syndrome is a rare idiopathic developmental condition characterized by midline craniofacial abnormalities. It was originally described as the presence of a median cleft lip, cutaneous polyps of the nasal m...
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Article
Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
COVID-19 is a pandemic caused by human coronavirus (HCoV) SARS-CoV-2, which originated in Wuhan, China, at the end of 2019 and spread globally during 2020. Due to the difficulty of clinical decision-making dur...
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Article
Clinical variability in children with dolichoarteriopathies of the internal carotid artery
Dolichoarteriopathies of the internal carotid artery (DICA) are frequent non-atheromatous anatomical changes in the general population. The etiology of DICA is still controversial: several hypotheses have been...
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Article
Gradenigo’s syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?
Gradenigo’s syndrome is defined by the classic clinical triad of ear discharge, trigeminal pain, and abducens nerve palsy. It has become a very rare nosological entity after the introduction of antibiotics, so...
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Open AccessWest-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery
West Nile virus (WNV) is a mosquito-borne RNA virus belonging to the Flaviviridae family. Symptomatic infection happens in only about 20% of the cases, while WNV neuroinvasive disease (WNND) is rare and accounts ...
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Open AccessClinical characteristics of headache in Italian adolescents aged 11–16 years: a cross-sectional questionnaire school-based study
The purpose of this study was to determine headache characteristics, impact on daily activities and medication attitudes among a large sample of adolescents in Italy.
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Open AccessNucleotide variation in Sabin type 3 poliovirus from an Albanian infant with agammaglobulinemia and vaccine associated poliomyelitis
Vaccine-associated paralytic poliomyelitis (VAPP) and immunodeficient long-term polio excretors constitute a significant public health burden and are a major concern for the WHO global polio eradication endgame.
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Paediatric clinically isolated syndromes: report of seven cases, differential diagnosis and literature review
Few paediatric cases of clinically isolated syndrome (CIS) have been described in literature, even though it has been increasingly recognized also in this age group. Our study retrospectively enrolled seven It...
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Article
Stickler syndrome associated with epilepsy: report of three cases
Stickler syndrome is a genetically heterogeneous collagenopathy characterized by auditory, ocular, musculoskeletal, and orofacial abnormalities. Stickler syndrome type 1 typically presents ophthalmologic invol...
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Article
Open AccessOmalizumab in Children
Omalizumab is a recombinant humanized monoclonal antibody that reduces levels of circulating immunoglobulin E (IgE) and expression of IgE high-affinity receptors on mast cells and basophils, interrupting the s...
