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Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics
The emergence and re-emergence of highly virulent viral pathogens with the potential to cause a pandemic creates an urgent need for the accelerated discovery of antiviral therapeutics. Antiviral human monoclon...
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Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
In Fig. 4b of this Article, the x-axis labels ‘PGT121’ and ‘GS-9620’ were inadvertently swapped in both graphs. In Fig. 5a, b, ‘TLR7’ should have been ‘GS-9620’. These figures have been corrected online.
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Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing ant...
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Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV
Antibodies are the primary correlate of protection for most licensed vaccines; however, their mechanisms of protection may vary, ranging from physical blockade to clearance via the recruitment of innate immuni...