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  1. Article

    Open Access

    HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial

    Autosomal dominant polycystic kidney disease (ADPKD) leads to progressive renal cyst formation and loss of kidney function in most patients. Vasopressin 2 receptor antagonists (V2RA) like tolvaptan are current...

    Thomas Bais, Esther Meijer, Bart J. Kramers, Priya Vart, Marc Vervloet in Trials (2024)

  2. Article

    Open Access

    Drugs in Clinical Development to Treat Autosomal Dominant Polycystic Kidney Disease

    Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of patients who receive kidney re...

    Thomas Bais, Ron T. Gansevoort, Esther Meijer in Drugs (2022)