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  1. No Access

    Protocol

    Unraveling DNA Organization with Single-Molecule Force Spectroscopy Using Magnetic Tweezers

    Genomes carry the genetic blueprint of all living organisms. Their organization requires strong condensation as well as carefully regulated accessibility to specific genes for proper functioning of their hosts...

    Thomas B. Brouwer, Artur Kaczmarczyk, Chi Pham, John van Noort in Bacterial Chromatin (2018)

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    Protocol

    Probing Chromatin Structure with Magnetic Tweezers

    Magnetic tweezers form a unique tool to study the topology and mechanical properties of chromatin fibers. Chromatin is a complex of DNA and proteins that folds the DNA in such a way that meter-long stretches o...

    Artur Kaczmarczyk, Thomas B. Brouwer, Chi Pham, Nynke H. Dekker… in Nanoscale Imaging (2018)