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Understanding mechanisms of racial disparities in breast cancer: an assessment of screening and regular care in the Carolina Breast Cancer Study
Screening history influences stage at detection, but regular preventive care may also influence breast tumor diagnostic characteristics. Few studies have evaluated healthcare utilization (both screening and pr...
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Article
Helicobacter pylori testing prior to or at gastric cancer diagnosis and survival in a diverse US patient population
Gastric cancer (GC) accounts for the greatest disparity in cancer mortality between Black and White Americans. Although clinical trials have shown that Helicobacter pylori (Hp) treatment reduces risk of GC, Hp te...
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Article
Open AccessLow-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial
As treatments for cancer have improved, more people are surviving cancer. However, compared to people without a history of cancer, cancer survivors are more likely to die of cardiovascular disease (CVD). Incre...
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Open AccessAuthor Correction: Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates
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Article
Open AccessCellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates
Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to gu...
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Article
Open AccessCharacterizing chronological accumulation of comorbidities in healthy veterans: a computational approach
Understanding patient accumulation of comorbidities can facilitate healthcare strategy and personalized preventative care. We applied a directed network graph to electronic health record (EHR) data and charact...
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Article
Time to surgery among women treated with neoadjuvant systemic therapy and upfront surgery for breast cancer
Time to surgery (TTS) is a potentially modifiable factor associated with survival after breast cancer diagnosis and can serve as a proxy for quality of oncologic care coordination. We sought to determine wheth...
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Article
Overall health at diagnosis predicts the risk of complications within the first year after breast cancer diagnosis
Breast cancer patients with overall poor health are at a greater risk of both complications during treatment and mortality from competing causes. We sought to determine the association of pre-existing comorbid...
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Article
Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age
Given presumed differences in disease severity between young (≤ 45 years) and elderly (≥ 75 years) women with breast cancer, we sought to compare tumor histopathology, stage at presentation, patterns of care, ...
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Article
Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients
Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective syste...
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Article
Open AccessMicroscaled proteogenomic methods for precision oncology
Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critic...
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Article
Open AccessAdvanced neoplasia in Veterans at screening colonoscopy using the National Cancer Institute Risk Assessment Tool
Adapting screening strategy to colorectal cancer (CRC) risk may improve efficiency for all stakeholders however limited tools for such risk stratification exist. Colorectal cancers usually evolve from advanced...
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Article
Adjuvant Chemotherapy Improves Survival Following Resection of Locally Advanced Rectal Cancer with Pathologic Complete Response
Controversy exists over the use of adjuvant chemotherapy for locally advanced (stages II–III) rectal cancer (LARC) patients who demonstrate pathologic complete response (pCR) following neoadjuvant chemoradiati...
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Article
Open AccessSplit tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients
The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the cancer ...
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Article
Latent class model characterization of neighborhood socioeconomic status
Neighborhood-level socioeconomic status (NSES) can influence breast cancer mortality and poorer health outcomes are observed in deprived neighborhoods. Commonly used NSES indexes are difficult to interpret. L...
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Article
Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer
The enumeration of circulating tumor cells (CTCs) provides important prognostic values in patients with metastatic breast cancer. Recent studies indicate that individual CTCs form clusters and these CTC-cluste...
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Article
Open AccessA Phase I study of AD5-GUCY2C-PADRE in stage I and II colon cancer patients
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Reference Work Entry In depth
Guanylyl Cyclase C as a Biomarker
Metastasis is the primary cause of death from colorectal cancer. In that context, overall survival and therapeutic response to adjuvant chemotherapy are most significantly governed by the presence of metastati...
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Article
Racial disparity in breast cancer survival: the impact of pre-treatment hematologic variables
A survival disparity of black versus white breast cancer patients has been extensively documented but not adequately explained. Blacks and whites also have significant differences in hematologic traits includ...
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Article
Erythropoiesis stimulating agents and clinical outcomes of invasive breast cancer patients receiving cytotoxic chemotherapy
The use of erythropoiesis stimulating agents (ESAs) to treat anemia in breast cancer patients who are treated with chemotherapy is a matter of ongoing debate. Several recent randomized trials challenged conven...
