7 Result(s)
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Article
Open AccessXanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure
Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and c...
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Article
Open AccessX chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study
The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phe...
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Article
Open AccessDSP variants may be associated with longitudinal change in quantitative emphysema
Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS)...
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Article
Open AccessChildhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study
Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood as...
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Article
Open AccessThe genetics of smoking in individuals with chronic obstructive pulmonary disease
Smoking is the principal modifiable environmental risk factor for chronic obstructive pulmonary disease (COPD) which affects 300 million people and is the 3rd leading cause of death worldwide. Most of the gene...
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Article
Open AccessEpidemiology, genetics, and subty** of preserved ratio impaired spirometry (PRISm) in COPDGene
Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammatio...
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Article
Open AccessNitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was...
