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Article
Open AccessGenome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait loci (rQTL) are often involved in gene-by-gene (G×...
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Article
Open AccessErratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Scientific Data 4:170179 doi: 10.1038/sdata.2017.179 (2017); Published 19 December 2017; Updated: 23 January 2018. In both the HTML and PDF versions of this Data Descriptor, the author name Jason Flannick was ...
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Article
Open AccessSequence data and association statistics from 12,940 type 2 diabetes cases and controls
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequenc...
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Article
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies hav...
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Article
Open AccessMitochondrial genomic variation associated with higher mitochondrial copy number: the Cache County Study on Memory Health and Aging
The mitochondria are essential organelles and are the location of cellular respiration, which is responsible for the majority of ATP production. Each cell contains multiple mitochondria, and each mitochondrion...
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Article
The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model
Variations in diabetic phenotypes are caused by complex interactions of genetic effects, environmental factors, and the interplay between the two. We tease apart these complex interactions by examining genome-...
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Article
Open AccessDeep resequencing reveals excess rare recent variants consistent with explosive population growth
Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has been unfeasible until now. Here, we applied Sange...
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Article
Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross
Quantitative trait locus (QTL) map** techniques are frequently used to identify genomic regions associated with variation in phenotypes of interest. However, the F2 intercross and congenic strain populations us...
