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Article
Open AccessTheranostic approach to specifically targeting the interloop region of BCL2 i-motif DNA by crystal violet
Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands, ...
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Article
Change in binding states between catabolite activating protein and DNA induced by ligand-binding: molecular dynamics and ab initio fragment molecular orbital calculations
The transcription mechanism of genetic information from DNA to RNA is efficiently controlled by regulatory proteins, such as catabolite activator protein (CAP), and their ligands. When cyclic AMP (cAMP) binds ...
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Article
Endoscopic treatment for esophageal varices complicated by Isaacs' syndrome involving difficulty with conventional sedation
A 54-year-old male consulted a local doctor with a chief complaint of systemic convulsions and muscle stiffness and was diagnosed with Isaacs' syndrome based on positive findings for antibodies against voltage...
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Article
A retrospective cohort study of partial splenic embolization for antiviral therapy in chronic hepatitis C with thrombocytopenia
Although partial splenic embolization (PSE) is reportedly effective prior to interferon (IFN)-based therapy, the number of subjects in these studies is small, and the appropriate candidates and disease prognos...
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Article
Temporal control during maintenance and extinction of conditioned keypecking in ring doves
Timing of conditioned keypecking was investigated using a delay autosha** procedure. In two experiments, the CS-US interval (ISI) was varied and the temporal pattern of responding during unreinforced probe t...
