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Article
Open AccessEmpagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal mice
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve heart failure (HF) outcomes across a range of patient characteristics. A hypothesis that SGLT2i induce metabolic change similar to fasting has recentl...
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Article
Open AccessKetone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart
Ketone body β-hydroxybutyrate (βOHB) and fibroblast growth factor-21 (FGF21) have been proposed to mediate systemic metabolic response to fasting. However, it remains elusive about the signaling elicited by ke...
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Article
Open AccessPathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction
Elevated intracardiac pressure at rest and/or exercise is a fundamental abnormality in heart failure with preserved ejection fraction (HFpEF). Fatty acid-binding protein 1 (FABP1) is proposed to be a sensitive...
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Article
Open AccessReduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy
Diabetes is an independent risk factor for the development of heart failure. Increased fatty acid (FA) uptake and deranged utilization leads to reduced cardiac efficiency and accumulation of cardiotoxic lipids...
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Article
Open AccessActivation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains uncl...
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Article
Open AccessExercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice
Skeletal muscle prefers carbohydrate use to fatty acid (FA) use as exercise intensity increases. In contrast, skeletal muscle minimizes glucose use and relies more on FA during fasting. In mice deficient for F...
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Reference Work Entry In depth
Fatty Acid Uptake by the Heart During Fasting
The heart consumes the highest energy substrates per weight in the entire body. The heart preferentially uses fatty acids (FAs) as energy-providing substrates; 60–90% of cardiac adenosine triphosphate (ATP) is...
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Article
Open AccessCirculating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption
Circulating fatty acid binding protein 4 (FABP4), secreted from adipocytes, is a potential biomarker for metabolic and cardiovascular diseases. Circulating FABP4 levels are positively associated with adiposity...
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Article
Open AccessMyocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure
The energy metabolism of the failing heart is characterized by reduced fatty acid (FA) oxidation and an increase in glucose utilization. However, little is known about how energy metabolism-function relationsh...
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Living Reference Work Entry In depth
Fatty Acid Uptake by the Heart During Fasting
The heart consumes the highest energy substrates per weight in the entire body. The heart preferentially uses fatty acids (FAs) as energy-providing substrates; 60–90% of cardiac adenosine triphosphate (ATP) is...
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Article
Erratum: Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice
Nature Communications 4: Article number: 2563 (2013); Published: 11 October 2013; Updated: 19 December 2013. In this Article, there are errors in the labelling of the x axes in Fig. 3. In panel e, the label ‘B...
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Article
Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice
Despite the established role of alveolar type II epithelial cells for the maintenance of pulmonary function, little is known about the deregulation of lipid composition in the pathogenesis of pulmonary fibrosi...
