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  1. Article

    Open Access

    A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with 19F NMR spectroscopy

    To develop a sensitive analytical method to quantify gemcitabine (2′,2′-difluorodeoxycytidine, dFdC) and its metabolites 2′,2′-difluorodeoxyuridine (dFdU) and 2′,2′-difluorodeoxycytidine-5′-triphosphate (dFdCT...

    Tashinga E. Bapiro, Frances M. Richards… in Cancer Chemotherapy and Pharmacology (2011)

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  2. No Access

    Article

    Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans

    To investigate the likelihood of artemisinin and thiabendazole causing pharmacokinetic interactions involving cytochrome P450 (CYP1A2) in humans given their potent inhibitory effects on the isoform in vitro.

    Tashinga E. Bapiro, Jane Sayi, Julia A. Hasler… in European Journal of Clinical Pharmacology (2005)

  3. No Access

    Article

    Cytochrome P 450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells

    Abstract

    Tashinga E. Bapiro, Tommy B. Andersson… in European Journal of Clinical Pharmacology (2002)