12 Result(s)

Article

Hemolytic versus malproductive anemia in large granular lymphocytic leukemia

Olisaemeka Ogbue, Tariq Kewan, Carlos Bravo-Perez, Serhan Unlu, Naomi Kawashima… in Leukemia (2024)

Article

Correction to: Treatment of Myelodysplastic Syndromes for Older Patients: Current State of Science, Challenges, and Opportunities

Tariq Kewan, Maximillian Stahl… in Current Hematologic Malignancy Reports (2024)

Article

Context-dependent role of trisomy 6 in myelodysplastic neoplasms and acute myeloid leukemia: a multi-omics analysis

Hussein Awada, Arda Durmaz, Tariq Kewan, Fauzia Ullah, Danai Dima, Hassan Awada… in Leukemia (2024)

Article

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

PHF6 mutations (PHF6^MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Here we show three main findings in our comprehensive ...

Yasuo Kubota, **aorong Gu, Laila Terkawi, Juraj Bodo… in Nature Communications (2024)

Article

Author Correction: Molecular patterns identify distinct subclasses of myeloid neoplasia

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari… in Nature Communications (2024)

Article

Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets

Complete or partial deletions of chromosome 7 (-7/del7q) belong to the most frequent chromosomal abnormalities in myeloid neoplasm (MN) and are associated with a poor prognosis. The disease biology of -7/del7q...

Minako Mori, Yasuo Kubota, Arda Durmaz, Carmelo Gurnari, Charnise Goodings… in Leukemia (2023)

Article

Novel scheme for defining the clinical implications of TP53 mutations in myeloid neoplasia

TP53 mutations (TP53^MT) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly le...

Waled Bahaj, Tariq Kewan, Carmelo Gurnari, Arda Durmaz… in Journal of Hematology & Oncology (2023)

Article

Molecular patterns identify distinct subclasses of myeloid neoplasia

Genomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological and clinical features have dominated the classical criteria for diagnosis and classificatio...

Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari… in Nature Communications (2023)

Article

New approaches to idiopathic neutropenia in the era of clonal hematopoiesis

Isolated chronic idiopathic neutropenia (CIN) is a rare disease with multiple contributing etiologies that must be ruled out before establishing a diagnosis. We studied clinical and molecular data of 238 conse...

Olisaemeka D. Ogbue, Tariq Kewan, Waled S. Bahaj… in Experimental Hematology & Oncology (2023)

Article

Is nature truly healing itself? Spontaneous remissions in Paroxysmal Nocturnal Hemoglobinuria

Carmelo Gurnari, Simona Pagliuca, Tariq Kewan, Waled Bahaj… in Blood Cancer Journal (2021)