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  1. No Access

    Article

    A novel mechanism for the store-operated calcium influx pathway

    Activation of store-operated channels (SOCs) and capacitative calcium influx are triggered by depletion of intracellular calcium stores. However, the exact molecular mechanism of such communication remains unc...

    Tarik Smani, Sergey I. Zakharov, Peter Csutora, Endri Leno… in Nature Cell Biology (2004)

  2. No Access

    Chapter

    Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry

    Activation of phospholipases A2 (PLA2) leads to the generation of biologically active lipid products that can affect numerous cellular events. Ca2+-independent PLA2 (iPLA2), also called group VI phospholipase A2,...

    Tarik Smani, Alejandro Domínguez-Rodriguez… in Calcium Entry Pathways in Non-excitable Ce… (2016)

  3. No Access

    Chapter

    Regulation of Platelet Function by Orai, STIM and TRP

    Agonist-induced changes in cytosolic Ca2+ concentration ([Ca2+]c) are central events in platelet physiology. A major mechanism supporting agonist-induced Ca2+ signals is store-operated Ca2+ entry (SOCE), where th...

    Alejandro Berna-Erro, Isaac Jardín… in Calcium Entry Pathways in Non-excitable Ce… (2016)

  4. No Access

    Living Reference Work Entry In depth

    Urocortin

    Tarik Smani in Encyclopedia of Signaling Molecules

  5. No Access

    Reference Work Entry In depth

    Urocortin

    Tarik Smani in Encyclopedia of Signaling Molecules (2018)

  6. No Access

    Chapter

    Molecular Basis and Regulation of Store-Operated Calcium Entry

    Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that...

    Jose J. Lopez, Isaac Jardin, Letizia Albarrán, Jose Sanchez-Collado… in Calcium Signaling (2020)

  7. No Access

    Chapter

    Pathophysiological Significance of Store-Operated Calcium Entry in Cardiovascular and Skeletal Muscle Disorders and Angiogenesis

    Store-Operated Ca2+ Entry (SOCE) is an important Ca2+ influx pathway expressed by several excitable and non-excitable cell types. SOCE is recognized as relevant signaling pathway not only for physiological proces...

    Javier Avila-Medina, Isabel Mayoral-González, Isabel Galeano-Otero… in Calcium Signaling (2020)

  8. Article

    Open Access

    Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells

    The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the question whether they exhibit dif...

    Jose Sanchez-Collado, Jose J. Lopez, Isaac Jardin… in Cellular and Molecular Life Sciences (2022)

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