-
Article
Infections of cardiac implantable electronic devices and how to improve transvenous lead extraction by the virtual reality
Infections in cardiac implantable electronic devices (CIED) are increasing over time and associated with substantially mortality and healthcare costs. The best approach is the complete removal of the system by...
-
Article
Open AccessOrai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells
Orai1 is the pore-forming subunit of the Ca2+-release activated Ca2+ channels that mediate store-operated Ca2+ entry (SOCE) in excitable and non-excitable cells. Two Orai1 forms have been identified in mammalian ...
-
Article
Open AccessOrai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the question whether they exhibit dif...
-
Living Reference Work Entry In depth
Considerations for Clinical Use of Mesenchymal Stromal Cells
The clinical application of stem cells continues to fascinate the scientific and clinical communities. Despite the controversies surrounding this field, it is clear that stem cells have revolutionized regenera...
-
Reference Work Entry In depth
Considerations for Clinical Use of Mesenchymal Stromal Cells
The clinical application of stem cells continues to fascinate the scientific and clinical communities. Despite the controversies surrounding this field, it is clear that stem cells have revolutionized regenera...
-
Reference Work Entry In depth
Mesenchymal Stromal Cells for COVID-19 Critical Care Patients
Despite the titanic efforts of health systems worldwide through the implementation of severe public health measures, the number of patients with the current coronavirus disease 2019 (COVID-19) has been dramati...
-
Living Reference Work Entry In depth
Mesenchymal Stromal Cells for COVID-19 Critical Care Patients
Despite the titanic efforts of health systems worldwide through the implementation of severe public health measures, the number of patients with the current coronavirus disease 2019 (COVID-19) has been dramati...
-
Chapter
Non-coding RNAs and Ischemic Cardiovascular Diseases
The Ischemic Heart Disease (IHD) is considered a clinical condition characterized by myocardial ischemia causing an imbalance between myocardial blood supply and demand, leading to morbidity and mortality acro...
-
Chapter
Molecular Basis and Regulation of Store-Operated Calcium Entry
Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that...
-
Chapter
Pathophysiological Significance of Store-Operated Calcium Entry in Cardiovascular and Skeletal Muscle Disorders and Angiogenesis
Store-Operated Ca2+ Entry (SOCE) is an important Ca2+ influx pathway expressed by several excitable and non-excitable cell types. SOCE is recognized as relevant signaling pathway not only for physiological proces...
-
Reference Work Entry In depth
Urocortin
-
Article
Open AccessmiR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemia-reperfusion injury
Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemia-reperfusion (I/R) injuries. However, little is known about their role in posttranscriptional regulation in th...
-
Living Reference Work Entry In depth
Urocortin
-
Article
Open AccessDynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry
Ca2+ influx by store-operated Ca2+ channels is a major mechanism for intracellular Ca2+ homeostasis and cellular function. Here we present evidence for the dynamic interaction between the SOCE-associated regulato...
-
Chapter
Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry
Activation of phospholipases A2 (PLA2) leads to the generation of biologically active lipid products that can affect numerous cellular events. Ca2+-independent PLA2 (iPLA2), also called group VI phospholipase A2,...
-
Chapter
Regulation of Platelet Function by Orai, STIM and TRP
Agonist-induced changes in cytosolic Ca2+ concentration ([Ca2+]c) are central events in platelet physiology. A major mechanism supporting agonist-induced Ca2+ signals is store-operated Ca2+ entry (SOCE), where th...
-
Article
A novel mechanism for the store-operated calcium influx pathway
Activation of store-operated channels (SOCs) and capacitative calcium influx are triggered by depletion of intracellular calcium stores. However, the exact molecular mechanism of such communication remains unc...
