3 Result(s)
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Tara T. Doucet-O’Hare
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Article
Open AccessDifferential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients
Comprising approximately 8% of our genome, Human Endogenous RetroViruses (HERVs) represent a class of germline retroviral infections that are regulated through epigenetic modifications. In cancer cells, which ...
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Article
Open AccessSMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 reg...
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Chapter
Retrotransposon Contribution to Genomic Plasticity
Genomic instability is strongly linked to the development and malignancy of cancer, and by studying premalignant conditions we can gain a better understanding of the sources of genomic instability and improve ...
