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Article
Revisiting the focal role of endostatin and environmental factors in Alzheimer’s disease
Alzheimer’s disease (AD) is a condition initiated by the assimilation of β-amyloid plaques (Aβ) and tau tangles, leading to neurodegeneration. It involves frequently cognitive decline as well as memory impairm...
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Article
Correction to: Deciphering the focal role of endostatin in Alzheimer’s disease
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Article
Correction to: Targeting cellular batteries for the therapy of neurological diseases
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Article
Correction to: Connecting the dots between mitochondrial dysfunction and Parkinson’s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity
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Article
Understanding the Pharmacological and Nanotechnological Facets of Dipeptidyl Peptidase-4 Inhibitors in Type II Diabetes Mellitus: a Paradigm in Therapeutics
The worldwide incidence of type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, is increasing rapidly. A newer category of oral hypoglycemic medications called dipeptidyl peptidases-4 (DPP-4) inhibit...
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Article
Molecular Chaperones as Therapeutic Target: Hallmark of Neurodegenerative Disorders
Misfolded and aggregated proteins build up in neurodegenerative illnesses, which causes neuronal dysfunction and ultimately neuronal death. In the last few years, there has been a significant upsurge in the le...
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Article
BIN1 in the Pursuit of Ousting the Alzheimer’s Reign: Impact on Amyloid and Tau Neuropathology
Alzheimer’s disease contributes to 60–70% of all dementia cases in the general population. Belonging to the BIN1/amphiphysin/RVS167 (BAR) superfamily, the bridging integrator (BIN1) has been identified to impa...
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Article
Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes playing a pivotal role in a num...
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Article
Traversing the Vivid Pharmacological and Nanotechnological Facets of Genistein: Insights into the Past, Present and Future Trends
The environment has endowed us with herbal remedies, which have a huge potential for alleviating human illnesses with minimal adverse effects. Genistein is one of isoflavones that possess a broad array of ther...
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Article
Insights into the Pivotal Role of Calcium Channel Blockers and Its Nanoformulations in the Management of Hypertension
Blood pressure that is consistently higher than the usual range of 120/80 mmHg is referred to as hypertension. As a person progresses to older age, hypertension become more prevalent and the persistently high ...
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Article
Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC)
Lung cancer is the most common type of cancer, with over 2.1 million cases diagnosed annually worldwide. It has a high incidence and mortality rate, leading to extensive research into various treatment options...
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Article
Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis
Rheumatoid arthritis is a systemic chronic polyarticular autoimmune disorder of joints and joint membrane mainly affecting feet and hands. The pathological manifestation of the disease includes infiltration of...
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Article
Open AccessAdvancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management. However, recent advances in molecular biology a...
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Article
Nanosilver-functionalized polysaccharides as a platform for wound dressing
Polysaccharides that are naturally sourced have enormous promise as wound dressings, due to their wider availability and reasonable cost and good biocompatibility. Furthermore, nanosilver extensively applied i...
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Article
Targeting multifunctional magnetic nanowires for drug delivery in cancer cell death: an emerging paradigm
Apoptosis, often known as programmed cell death is a mechanism used by numerous species to maintain tissue homeostasis. The process leading to cell death is complicated because it requires the stimulation of c...
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Article
Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer’s disease
Medicinal plants are being used from time immemorial for their therapeutic benefits and have immense value in the therapy of neurodegenerative disorders. One of the most important neurological disorders is Alz...
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Article
Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson’s Disease: A Novel and Futuristic Approach
Parkinson’s disease is a neurodegenerative disorder which is characterised mostly by loss of dopaminergic nerve cells throughout the nigral area mainly as a consequence of oxidative stress. Muscle stiffness, d...
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Article
Exploring the role of exosomes in rheumatoid arthritis
In prosperous countries, autoimmune illnesses affect minimum 7% of the community. Rheumatoid Arthritis (RA) as an autoimmune illness is thought to be induced through a variety of genomic, physiological, and bi...
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Article
Focusing COVID-19-associated mucormycosis: a major threat to immunocompromised COVID-19
COVID-19 disease has been identified to cause remarkable increase of mucormycosis infection cases in India, with the majority of cases being observed in individuals recovering from COVID-19. Mucormycosis has e...
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Article
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2). ROS are typically produced under physiological conditions and play crucial roles in living organisms. It is known that ROS, wh...
