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Article
Phase-Field Modeling of Thermal Fracture and Shear Heating in Rocks with Degraded Thermal Conductivity Across Crack
By incorporating two different fracture mechanisms and salient unilateral effects in rock materials, we propose a thermomechanical phase-field model to capture thermally induced fracture and shear heating in t...
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Article
Open AccessA study on the differential of solid lung adenocarcinoma and tuberculous granuloma nodules in CT images by Radiomics machine learning
To study the classification efficiency of using texture feature machine learning method in distinguishing solid lung adenocarcinoma (SADC) and tuberculous granulomatous nodules (TGN) that appear as solid nodul...
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Article
Open AccessDifferent interventions for the treatment of patent ductus arteriosus in children: a protocol for a network meta-analysis
Patent ductus arteriosus (PDA) is one of the most common congenital heart diseases. Once the PDA is diagnosed, it needs to be dealt with in time. At present, main methods include pharmacological treatment, sur...
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Article
Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation
The toxicity of lead (Pb) has been intensively studied, while the adverse effects in the population on a high-fat diet (HFD) remain unclear. This study compared the different biologic effects of Pb in CHOW and...
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Article
Open AccessGender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis
The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of...
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Article
Open AccessCardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias
Abnormal myocardial Nav1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO...
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Article
Pulsar wind nebulae contribution to positron excess in AMS-02 data
In this project, we investigate several existing paradigms seeking to explain the origin of positron energy flux excess as shown in the latest cosmic ray (CR) data from alpha magnetic spectrometer (AMS-02) cur...
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Article
Open AccessTranscatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis
Although transcatheter technology has achieved some success in the field of mitral valves, the feasibility of applying it to patients with degenerated mitral valve bioprostheses (valve-in-valve, ViV), failure ...
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Article
CCN1 gene polymorphisms associated with congenital heart disease susceptibility in Northwest Chinese population from different high-altitude areas
High-altitude hypoxic environment exposure is considered one of the risk factors for congenital heart disease (CHD), but the genetic factors involved are still unclear. CCN1, one of the synergistic molecules i...
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Article
Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo
Long non-coding RNA (lncRNA) plays a pivotal role in the development of myocardial infarction (MI). The aim of this study was to investigate the effects of lncRNA actin filament-associated protein 1 antisense ...
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Article
Open AccessThe study of automatic machine learning base on radiomics of non-focus area in the first chest CT of different clinical types of COVID-19 pneumonia
To explore the possibility of predicting the clinical types of Corona-Virus-Disease-2019 (COVID-19) pneumonia by analyzing the non-focus area of the lung in the first chest CT image of patients with COVID-19 b...
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Article
Open AccessLaparoscopic based renal denervation in a canine neurogenic hypertension model
Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervat...
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Article
Open AccessGlobal diastolic strain rate for the assessment of left ventricular diastolic dysfunction in young peritoneal dialysis patients: a case control study
Left ventricular (LV) myocardial longitudinal diastolic strain rate measured by two-dimensional speckle tracking imaging (2D-STI) was proved to have a better correlation with the LV diastolic function. We aime...
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Article
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Accumulating evidence suggests that C-type lectin-like receptor-2 (CLEC-2) plays an important role in atherothrombosis. In this case-control study, we investigated the association between CLEC-2 and incidence ...
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Article
Open AccessDedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness
Differentiated cancer cells reacquiring stem cell traits following radiotherapy may enrich cancer stem cells and accelerate tumor recurrence and metastasis. We are interested in the mechanistic role of dying c...
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Article
Open AccessFormation of Pseudomonas aeruginosa Biofilms in Full-thickness Scald Burn Wounds in Rats
Using Sprague-Dawley rats (350–450 g; n = 61) and the recently updated Walker-Mason rat scald burn model, we demonstrated that Pseudomonas aeruginosa readily formed biofilms within full-thickness burn wounds. Fol...
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Article
Open AccessCorrelation between pri-miR-124 (rs531564) polymorphism and congenital heart disease susceptibility in Chinese population at two different altitudes: a case-control and in silico study
The development of congenital heart disease (CHD) is a complicated process and affected by multiple environmental factors, as genetic factors, and the interactions among those factors. Previous studies have sh...
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Chapter
Nano-MoS2 and Graphene Additives in Oil for Tribological Applications
Nano-additives have attracted lots of attentions in recent years due to their special performances. A traditional lubricating additive MoS2 with nano-scale and a novel additive graphene were reviewed in this chap...
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Article
Abating recrystallization inhomogeneity in twin-roll cast 3003 aluminum sheet by electromagnetic fields
Recrystallization inhomogeneity is a typical problem in twin-roll cast Al–Mn alloys. A compound field is applied during twin-roll casting of 3003 aluminum sheet to investigate its effects on the final recrysta...
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Article
Open AccessIL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling
Spinal cord injury is a grave neurological disability resulting in neuron degeneration and permanent paralysis. The inflammation triggered by the injury would promote the spinal cord lesion in turn. Activated ...
