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Chapter and Conference Paper
Motif Analysis of Resting-state and Stimulus-driven fMRI Networks with Special Focus on Neurotransmitter-specific Subnetworks 2023
Complex large scale brain networks can be broken down to small, repetitive building blocks, termed motifs. Here, motif-compositions were investigated in functional brain networks of different mouse models of A...
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Chapter and Conference Paper
Attention-based Multiple Instance Learning for Survival Prediction on Lung Cancer Tissue Microarrays
Attention-based multiple instance learning (AMIL) algorithms have proven to be successful in utilizing gigapixel whole-slide images (WSIs) for a variety of different computational pathology tasks such as outco...
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Article
Open AccessSevere T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils,...
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Article
Open AccessExcellent histological results in terms of articular cartilage regeneration after spheroid-based autologous chondrocyte implantation (ACI)
Traumatic lesions of articular cartilage represent a crucial risk factor for osteoarthritis. Even if several strategies exist to treat such damages, the optimal solution has not yet been found. A new strategy ...
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Article
Open AccessCompared DNA and RNA quality of breast cancer biobanking samples after long-term storage protocols in − 80 °C and liquid nitrogen
Molecular investigations are crucial for further developments in precision medicine. RNA sequencing, alone or in combination with further omic-analyses, resulted in new therapeutic strategies. In this context,...
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Article
Open AccessSubstance P modulates bone remodeling properties of murine osteoblasts and osteoclasts
Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies...
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Article
The impact of hypoxia on mesenchymal progenitor cells of human skeletal tissue in the pathogenesis of heterotopic ossification
Mesenchymal progenitor cells (MPCs) are capable of differentiating into osteo/chondrogenic cells to contribute substantially to heterotopic ossification (HO). This study aimed to examine the impact of hypoxia ...
