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Article

Generation of genetically modified mice using SpCas9-NG engineered nuclease

Although genetically modified mice can be generated with high efficiency by using CRISPR/Cas9-mediated genome editing in mouse zygotes, only the loci with a protospacer-adjacent motif (PAM) sequence are target...

Wataru Fujii, Haruka Ito, Takuya Kanke, Arisa Ikeda, Koji Sugiura… in Scientific Reports (2019)