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Article
Open AccessFactors associated with visual field or structure progression occurring first in a prospective study on patients with untreated open-angle glaucoma with normal intraocular pressure
To identify factors associated with disc/retina deterioration in stereo fundus photographs preceding that of the visual field (VF), as determined with a Humphrey Field Analyzer (HFA) (Structure First deteriora...
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Article
Changes in choroidal thickness in healthy participants after induction of sympathetic hyperactivity using the cold pressor test
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Article
Peripapillary choroidal thickness assessed by spectral-domain optical coherence tomography in normal Japanese
To investigate peripapillary choroidal thickness (PPCT) in normal Japanese subjects by using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) technique and evaluate its a...
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Article
Long-term regular exercise and intraocular pressure: the Hisayama Study
To investigate the association between long-term regular exercise (exercise frequency and exercise time) and 5-year changes in intraocular pressure in a general Japanese population.
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Article
Open AccessAdditive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model
In a rat ex vivo acute glaucoma model, high pressure (75 mmHg) causes swelling of ganglion cell axons and elevates levels of the endogenous steroids 24(S)-hydroxycholesterol (24SH) and allopregnanolone (AlloP). F...
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Article
Open AccessAssessment of Central Visual Function in Patients with Retinitis Pigmentosa
In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examin...
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Article
Effects of ripasudil hydrochloride hydrate (K-115), a Rho-kinase inhibitor, on ocular blood flow and ciliary artery smooth muscle contraction in rabbits
Ripasudil, a Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor, is a novel drug for glaucoma in Japan. ROCK inhibition not only reduces intraocular pressure (IOP) but also increases ocular ...
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Article
Open AccessLong noncoding RNAs coordinate functions between mitochondria and the nucleus
In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial-specific nucleic acids and proteins. To maintain homeostasis of the en...
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Article
Open Access24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure
In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by cholesterol 24-hydroxylase (CYP46A1) encoded by the cyp46a1 gene. In the present study using a ra...
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Article
Dorzolamide-induced relaxation of isolated rabbit ciliary arteries mediated by inhibition of extracellular calcium influx
The carbonic anhydrase inhibitor dorzolamide can increase optic nerve blood flow. The aim of the study reported here was to investigate the effect of dorzolamide on isolated rabbit ciliary arteries that supply...
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Article
Open AccessMorning glory disc anomaly with contractile movements
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Article
Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries
In normotensive eyes, reduced ocular blood flow can lead to glaucoma pathogenesis. Drugs that reduce intraocular pressure (IOP) often cause vasodilation of the ciliary arteries and improve blood flow to the ey...
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Article
Spontaneous closure of a stage 2 macular hole without detachment of the posterior hyaloid
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Article
Temperature-dependent ultrastructural changes in the cone interphotoreceptor matrix
To determine the temperature-dependent ultrastructural changes of the cone matrix sheath, a possible critical factor in the adhesive strength binding photoreceptors and pigment epithelial cells.
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Article
Effect and Mechanism of Betaxolol and Timolol on Vascular Relaxation in Isolated Rabbit Ciliary Artery
In order to clarify the vasodilatory mechanism of betaxolol and timolol, we studied the effects of these drugs in isolated rabbit ciliary arteries.
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Article
Effect of Immunosuppression on Survival of Allograft Limbal Stem Cells
To examine whether the application of immunosuppression enhances the survival of limbal allograft stem cells.
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Article
Multiple retinal holes in the macular region: a case report
Purpose. To describe the first case of multiple retinal holes in the macular region successfully treated with vitrectomy.
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Article
Electron microscopic study of monkey retina after photodynamic treatment
The purpose of this histological study was to determine the effects of photodynamic treatment, using a hematoporphyrin derivative and argon laser, on normal retinas of monkeys. Ten cynomolgus monkeys were tre...
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Article
Pharmacological effects of latanoprost, prostaglandin E2, and F2 α on isolated rabbit ciliary artery
Background: Latanoprost is a prostaglandin (PG)F2 α analogue widely recognized in the treatment of glaucoma. To investigate the action of this drug on the ocular ...
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Article
Effect of histamine and substance P on the rabbit and human iris sphincter muscle
• Background and methods: In an attempt to clarify the functional action of histamine and substance P on atropine-resistant miosis, we isolated rabbit and human iris sphincter muscles and investigated their me...
