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Article
Open AccessGWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have implicated the involvement of the fatty acid desaturase (FADS) locus. These enzymes (FADS1 and FADS2) are involved in the metaboli...
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Article
Genetic map** of simply inherited categorical traits, including anthocyanin accumulation profiles and fruit appearance, in eggplant (Solanum melongena)
The appearance quality of the eggplant (Solanum melongena L.) fruit is an important trait that influences its commercial value. It is known that quality traits such as anthocyanin composition and fruit surface pa...
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Article
Open AccessCost effectiveness of pharmacogenetic-guided clozapine administration based on risk of HLA variants in Japan and the UK
Pharmacogenetics/pharmacogenomics have enabled the detection of risk of human leukocyte antigen (HLA) variants for clozapine-induced agranulocytosis/granulocytopenia (CIAG). To apply this evidence to the clini...
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Article
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 6...
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Article
Open AccessIdentification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region
SLC6A4, which encodes the serotonin transporter, has a functional polymorphism called the serotonin transporter-linked polymorphic region (5-HTTLPR). The 5-HTTLPR consists of short (S) and long (L) alleles, each ...
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Article
Maladaptive photoperiodic response in an invasive alien insect, Milionia basalis pryeri (Lepidoptera: Geometridae), in southern Kyushu, Japan
The geometrid moth, Milionia basalis pryeri Druce, is an important pest of Podocarpaceae trees that has recently become established in the southern part of the main island of Kyushu, Japan. The species exhibits a...
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Article
Detailed map** of a resistance locus against Fusarium wilt in cultivated eggplant (Solanum melongena)
This is the first report on genetic map** of a resistance locus against Fusarium wilt caused by the plant pathogen Fusarium oxysporum ...
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Article
Development of selective markers linked to a major QTL for parthenocarpy in eggplant (Solanum melongena L.)
Parthenocarpy, the ability to set fruits without pollination, is a useful trait for setting fruit under unfavorable conditions. To identify the loci controlling parthenocarpy in eggplant (Solanum melongena L.), w...
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Article
A case of breast cancer metastatic to the head of the pancreas
A case of breast cancer that metastasized to the head of the pancreas 6 years and 8 months after mastectomy is reported. The pancreas head metastasis was associated with general fatigue and obstructive jaundic...
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Article
A case of breast cancer metastatic to the pituitary gland
A case of breast cancer that developed pituitary metastasis 22 years after mastectomy is reported. The pituitary metastasis was associated with hypopituitarism, impairment of the visual field and later diabete...
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Article
Improved culture conditions for somatic embryogenesis from Asparagus officinalis L. using an aseptic ventilative filter
Calli were induced from the crown of seedlings or lateral bud of young spears of Asparagus officinalis L. on Linsmaier and Skoog's (LS) solid-medium supplemented with 5 μ M 2,4-dichlorophenoxyacetic acid (2,4-D)....
