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  1. Article

    Open Access

    Model-based prediction of spatial gene expression via generative linear map**

    Decoding spatial transcriptomes from single-cell RNA sequencing (scRNA-seq) data has become a fundamental technique for understanding multicellular systems; however, existing computational methods lack both ac...

    Yasushi Okochi, Shunta Sakaguchi, Ken Nakae, Takefumi Kondo… in Nature Communications (2021)

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  2. No Access

    Article

    On a question of Gromov about the Wirtinger inequalities

    We prove that Gromov’s \(\mathrm {Cycl}_4(0)\)

    Takefumi Kondo, Tetsu Toyoda, Takato Uehara in Geometriae Dedicata (2018)

  3. No Access

    Article

    Uniform Estimates of Nonlinear Spectral Gaps

    By generalizing the path method, we show that nonlinear spectral gaps of a finite connected graph are uniformly bounded from below by a positive constant which is independent of the target metric space. We app...

    Takefumi Kondo, Tetsu Toyoda in Graphs and Combinatorics (2015)

  4. No Access

    Article

    Pri peptides are mediators of ecdysone for the temporal control of development

    Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal con...

    Hélène Chanut-Delalande, Yoshiko Hashimoto, Anne Pelissier-Monier… in Nature Cell Biology (2014)

  5. No Access

    Article

    TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

    The authors show that shortening of the basal process in neural progenitor cells by depletion of TAG-1 results in overcrowding in the periventricular space and, eventually, delamination and aberrant migration....

    Mayumi Okamoto, Takashi Namba, Tomoyasu Shinoda, Takefumi Kondo… in Nature Neuroscience (2013)

  6. No Access

    Article

    Mitotic cell rounding accelerates epithelial invagination

    Drosophila epithelial tracheal placode invagination is shown to be driven by mitotic cell rounding along with epithelial growth factor receptor signalling and myosin contractility in neighbouring cells, revealing...

    Takefumi Kondo, Shigeo Hayashi in Nature (2013)

  7. No Access

    Article

    CAT(0) spaces and expanders

    We construct a CAT(0) space Y with Izeki–Nayatani invariant δ(Y) = 1. By a similar construction, we also prove that there exists a CAT(0) space which does not have Markov type p for every p > 1.

    Takefumi Kondo in Mathematische Zeitschrift (2012)

  8. No Access

    Article

    Fixed-point property of random groups

    In this paper, using the generalized version of the theory of combinatorial harmonic maps, we give a criterion for a finitely generated group Γ to have the fixed-point property for a certain class of Hadamard ...

    Hiroyasu Izeki, Takefumi Kondo, Shin Nayatani in Annals of Global Analysis and Geometry (2009)

  9. No Access

    Article

    Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA

    Transcriptome analyses in eukaryotes, including mice and humans, have identified polyA-containing transcripts that lack long open reading frames (ORFs; >100 amino acids)1,2. These transcripts are believed most li...

    Takefumi Kondo, Yoshiko Hashimoto, Kagayaki Kato, Sachi Inagaki… in Nature Cell Biology (2007)