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  1. Article

    Open Access

    Development of extended pharmacokinetic models for propofol based on measured blood and brain concentrations

    Propofol’s pharmacokinetics have been extensively studied using human blood samples and applied to target-controlled infusion systems; however, information on its concentration in the brain remains scarce. The...

    Masayoshi Kawata, Atsushi Yonezawa, Yohei Mineharu, Kotaro Itohara in Scientific Reports (2024)

  2. Article

    Open Access

    Pre-stroke physical activity is associated with post-stroke physical activity and sedentary behavior in the acute phase

    This study investigated the link between pre-stroke and acute-stage physical activity (PA) and sedentary behavior. Forty individuals with stroke (aged 73.6 ± 8.9 years) were enrolled. Post-stroke activity, inc...

    Hiroki Tanaka, Gakuto Kitamura, Mayu Tamura, Manabu Nankaku in Scientific Reports (2023)

  3. Article

    Open Access

    Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images

    Preoperative glioma grading is important for therapeutic strategies and influences prognosis. Intratumoral heterogeneity can cause an underestimation of grading because of the sampling error in biopsies. We de...

    Rika Inano, Naoya Oishi, Takeharu Kunieda, Yoshiki Arakawa in Scientific Reports (2016)